null

Human CD226 Recombinant Protein (RPPB3043)

SKU:
RPPB3043
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15762
Research Area:
CD Antigens
€309
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human CD226 Recombinant Protein
Product Code:RPPB3043
Size:20µg
Species:Human
Target:CD226
Synonyms:DNAM-1, PTA1, TLiSA1, CD226 antigen, DNAX accessory molecule 1, DNAM1, Recombinant Human CD226.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CD226 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QSDSFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNQYTLFVA

CD226 belongs to the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 is a 65kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. CD226 facilitates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. CD226 also plays a role in megakaryocytic cell maturation.

CD226 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 259 amino acids (19-254a.a.) and having a molecular mass of 29.4kDa.CD226 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function:integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; cell adhesion; signal transduction; positive regulation of mast cell activation

NCBI Summary:This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
UniProt Code:Q15762
NCBI GenInfo Identifier:317373338
NCBI Gene ID:10666
NCBI Accession:Q15762.2
UniProt Secondary Accession:Q15762,B2R818,
UniProt Related Accession:Q15762
Molecular Weight:
NCBI Full Name:CD226 antigen
NCBI Synonym Full Names:CD226 molecule
NCBI Official Symbol:CD226��
NCBI Official Synonym Symbols:PTA1; DNAM1; DNAM-1; TLiSA1��
NCBI Protein Information:CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen
UniProt Protein Name:CD226 antigen
UniProt Synonym Protein Names:DNAX accessory molecule 1
Protein Family:CD226 antigen
UniProt Gene Name:CD226��
UniProt Entry Name:CD226_HUMAN

Related Products