Human CD1E Recombinant Protein (RPPB3013)
- SKU:
- RPPB3013
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15812
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD1E Recombinant Protein |
| Product Code: | RPPB3013 |
| Size: | 20µg |
| Species: | Human |
| Target: | CD1E |
| Synonyms: | CD1A, R2, T-cell surface glycoprotein CD1e, membrane-associated, R2G1, sCD1e. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CD1E protein solution (1mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEEQLSFR MLQTSSFANH SWAHSEGSGW LGDLQTHGWD TVLGTIRFLKPWSHGNFSKQ ELKNLQSLFQ LYFHSFIQIV QASAGQFQLE YPFEIQILAG CRMNAPQIFL NMAYQGSDFLSFQGISWEPS PGAGIRAQNI CKVLNRYLDI KEILQSLLGH TCPRFLAGLM EAGESELKRK VKPEAWLSCGPSPGPGRLQL VCHVSGFYPK PVWVMWMRGE QEQRGTQRGD VLPNADETWY LRATLDVAAG EAAGLSCRVKHSSLGGHDLI IHWGGYS |
CD1E belongs to the CD1family of transmembrane glycoproteins which are structurally associated to the mainMHC (histocompatibility complex) proteins and form heterodimers withbeta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipidand glycolipid antigens of self or microbial origin to T cells. The humangenome is comprised of 5 CD1 family genes organized in a cluster on chromosome1. The CD1 family members are belief to differ in their cellular localizationand specificity for particular lipid ligands. CD1E localizes within Golgicompartments, endosomes, and lysosomes, and is cleaved into a steady solubleform. The soluble form is necessary for the intracellular processing of someglycolipids into a form that can be presented by other CD1 family members.
CD1E Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 297 amino acids (32-305 a.a) andhaving a molecular mass of 33.1kDa.CD1E is fused to a 23 amino acid His-tag at N-terminus &purified by proprietary chromatographic techniques.
| UniProt Protein Function: | T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P15812 |
| NCBI GenInfo Identifier: | 14030479 |
| NCBI Gene ID: | 913 |
| NCBI Accession: | AAK52914.1 |
| UniProt Secondary Accession: | P15812,Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8 Q5TDL1, Q712E4, Q712E5 |
| UniProt Related Accession: | P15812 |
| Molecular Weight: | 32,303 Da |
| NCBI Full Name: | CD1E, partial |
| NCBI Synonym Full Names: | CD1e molecule |
| NCBI Official Symbol: | CD1E�� |
| NCBI Official Synonym Symbols: | R2; CD1A�� |
| NCBI Protein Information: | T-cell surface glycoprotein CD1e, membrane-associated |
| UniProt Protein Name: | T-cell surface glycoprotein CD1e, membrane-associated |
| UniProt Synonym Protein Names: | R2G1; CD_antigen: CD1e |
| Protein Family: | T-cell surface glycoprotein |
| UniProt Gene Name: | CD1E�� |
| UniProt Entry Name: |
