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PE/Cyanine7 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1806)

SKU:
AGEL1806
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
G043H7
Conjugation:
PE/Cy7
$311 - $1,067
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody PE-Cyanine7 Conjugated (G043H7-AGEL1806) is a cutting-edge tool designed for researchers interested in studying CCR7, a key chemokine receptor involved in immune cell migration and homing. This monoclonal antibody, conjugated with PE-Cyanine7 for fluorescence-based applications, specifically targets the human CD197 (CCR7) protein, enabling precise detection and analysis in various experimental settings.CCR7 is known for its critical role in regulating lymphocyte migration to secondary lymphoid organs and orchestrating immune responses. Its implications in immune surveillance, inflammation, and homeostasis make it a crucial target for investigation in immunology, vaccine development, and cancer research.

The CD197 (CCR7) Monoclonal Antibody provides researchers with a reliable tool to explore the expression, localization, and functional roles of CCR7 in different cell types and disease models.By utilizing this antibody, researchers can gain valuable insights into the mechanisms underlying immune cell trafficking, immune surveillance, and adaptive immune responses. Its specificity, sensitivity, and compatibility with fluorescence-based techniques make it an essential resource for studies aiming to understand the complex interplay of chemokine receptors in immune regulation and disease pathogenesis.

Product Title:PE/Cyanine7 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1806
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine7 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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