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PE/Cyanine5 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1805)

SKU:
AGEL1805
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$311 - $1,067
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Description

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PE/Cyanine5 Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody PE-Cyanine5 Conjugated (G043H7-AGEL1805) offered by Assay Genie is a powerful tool for researchers studying the CCR7 protein, which is a critical chemokine receptor involved in immune cell trafficking and homing. This antibody is specifically designed for flow cytometry applications, allowing for the precise detection and analysis of CCR7 expression in human samples.CCR7 is known to play a key role in immune responses, particularly in directing the migration of T cells and dendritic cells to secondary lymphoid organs. Its dysregulation has been associated with various inflammatory and autoimmune conditions, as well as cancer metastasis.

By using this monoclonal antibody, researchers can gain valuable insights into the role of CCR7 in these processes and potentially identify novel therapeutic targets for related diseases.With its high specificity and sensitivity, the Human CD197 (CCR7) Monoclonal Antibody PE-Cyanine5 Conjugated (G043H7-AGEL1805) is a reliable tool for immunology and cancer research studies focused on understanding the function of CCR7 in immune cell migration and activation. Its validated performance in flow cytometry makes it an ideal choice for investigating the role of CCR7 in various physiological and pathological contexts.

Product Title:PE/Cyanine5 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1805
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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