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PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1807)

SKU:
AGEL1807
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$311 - $1,067
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody (PE-Cyanine5.5 Conjugated) is a specialized tool for researchers studying the cell surface molecule CD197 (CCR7), which is essential for immune cell trafficking and lymphocyte homing. This antibody, derived from mouse monoclonal sources, offers high specificity and sensitivity for detecting human CD197 (CCR7) in various cellular contexts.CD197 (CCR7) plays a pivotal role in the migration of T cells and dendritic cells to lymphoid organs, aiding in immune surveillance and response. Its functions in directing immune cell movement make it a key target for investigations related to immune system function, inflammation, and immune-related diseases. This antibody's conjugation with PE-Cyanine5.5 enables convenient flow cytometry applications for precise analysis and characterization of CD197 (CCR7)-expressing cells.

With its ability to specifically target CD197 (CCR7) in human samples, this monoclonal antibody is a valuable tool for research in immunology, cancer biology, and infectious diseases. By facilitating the identification and profiling of CD197 (CCR7)-positive cells, researchers can gain insights into immune cell behaviors and responses, contributing to advancements in therapies targeting immune cell migration and function.By using the Human CD197 (CCR7) Monoclonal Antibody (PE-Cyanine5.5 Conjugated), researchers can delve deeper into the intricate mechanisms of immune cell trafficking and lymphoid tissue interactions, paving the way for discoveries that could impact the development of immunotherapies and treatment strategies for immune-related disorders.

Product Title:PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1807
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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