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GenieFluor 647 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1810)

SKU:
AGEL1810
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$263 - $839
Frequently bought together:

Description

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GenieFluor 647 Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody (AF647 Conjugated, G043H7-AGEL1810) is a cutting-edge tool for researchers investigating the role of the chemokine receptor CCR7 in immune cell trafficking and homing processes. This antibody, specifically engineered for use in flow cytometry and immunofluorescence applications, offers high specificity and sensitivity in detecting CCR7 expression in human samples.CCR7 is a key chemokine receptor involved in directing immune cell migration to secondary lymphoid tissues and sites of inflammation. Its precise regulation is crucial for orchestrating immune responses and maintaining immune surveillance.

By targeting CCR7 with this monoclonal antibody, researchers can gain insights into the mechanisms underlying immune cell recruitment and activation, providing valuable information for studies in immunology, vaccine development, and inflammatory disorders.With its superior performance and reliability, the Human CD197 (CCR7) Monoclonal Antibody (AF647 Conjugated, G043H7-AGEL1810) is a valuable tool for elucidating the complex interplay of chemokine signaling in immune system function and pathology. Invest in this innovative antibody to advance your research and unlock new discoveries in the field of immunology.

Product Title:GenieFluor 647 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1810
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Genie Fluor 647 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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