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GenieFluor 488 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1809)

SKU:
AGEL1809
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€219 - €699
Frequently bought together:

Description

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GenieFluor 488 Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody (AF488 Conjugated) (G043H7-AGEL1809) from Assay Genie is a cutting-edge tool for researchers interested in the study of CCR7, a cell surface receptor involved in lymphocyte trafficking and immune response modulation. This monoclonal antibody, conjugated with AF488 for advanced fluorescent detection, is specifically designed for use in flow cytometry and immunofluorescence applications.CCR7, also known as chemokine receptor 7, plays a crucial role in directing the migration of immune cells to secondary lymphoid organs and sites of inflammation. This antibody, meticulously developed and validated by Assay Genie, offers high specificity and sensitivity for detecting CCR7 expression in human samples.

Its use enables precise visualization and quantification of CCR7-positive cells, aiding in the investigation of immune cell localization and function.By utilizing the Human CD197 (CCR7) Monoclonal Antibody (AF488 Conjugated), researchers can deepen their understanding of immune cell trafficking, immune responses, and the role of CCR7 in various physiological and pathological conditions. This versatile antibody is a valuable asset for studies in immunology, inflammation, and cancer research, providing insights that may lead to the development of novel therapeutic approaches targeting CCR7-mediated immune processes.

Product Title:GenieFluor 488 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1809
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Genie Fluor 488 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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