The CD18 Monoclonal Antibody (FITC Conjugated) TS1/18.1.2.11 (AGEL0241) from Assay Genie is a powerful tool for researchers studying the CD18 protein, an essential component of the integrin family involved in cell adhesion and migration. This antibody, generated using the TS1/18.1.2.11 hybridoma, is conjugated with FITC for easy detection and visualization in flow cytometry and immunofluorescence experiments.CD18, also known as Integrin beta-2, plays a crucial role in immune cell function by mediating interactions between leukocytes and endothelial cells during inflammation and immune responses. By targeting CD18, researchers can investigate mechanisms underlying immune cell recruitment, adhesion, and signaling, providing insights into various diseases such as inflammatory disorders, autoimmune conditions, and infectious diseases.
With its high specificity and sensitivity, the FITC-conjugated CD18 Monoclonal Antibody from Assay Genie offers reliable results in a wide range of applications, including cellular assays and in vivo studies. By utilizing this antibody, scientists can uncover novel findings regarding the role of CD18 in immune regulation and potentially develop therapeutic strategies targeting integrin-mediated processes.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P05107
Gene ID:
3689
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains function in adhesion and signaling in hematopoietic cells.
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