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PE/Cyanine7 Anti-Human CD123 Antibody [6H6] (AGEL1459)

SKU:
AGEL1459
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€219 - €709
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human CD123 Antibody [6H6]

The Human CD123 Monoclonal Antibody (PE/Cyanine7 Conjugated) (6H6) is a powerful tool for research involving CD123, a cell surface marker predominantly found on plasmacytoid dendritic cells and a subset of myeloid progenitors. This monoclonal antibody, labeled with PE/Cyanine7 for enhanced sensitivity in flow cytometry assays, specifically targets CD123, allowing for precise detection and analysis in various immune cell populations.CD123, also known as interleukin-3 receptor alpha chain, plays a crucial role in the development and function of specific immune cells, making it a key target for investigation in immunology and hematological research. Its overexpression has been identified in certain leukemias, highlighting its diagnostic and therapeutic potential in cancer studies.

By facilitating the detection of CD123-expressing cells, this antibody is essential for understanding the role of CD123 in disease pathogenesis and evaluating its potential as a therapeutic target. The Human CD123 Monoclonal Antibody (PE/Cyanine7 Conjugated) (6H6) from Assay Genie is a reliable tool for researchers seeking to unravel the complexities of immune cell biology, particularly in the context of hematological malignancies and immune disorders. With its high specificity and sensitivity, this antibody enables precise and accurate detection of CD123-expressing cells, contributing to advancements in both basic research and clinical applications.

Product Title:PE/Cyanine7 Anti-Human CD123 Antibody [6H6]
SKU:AGEL1459
Size:20 Tests, 100 Tests, 200 Tests
Clone No:6H6
Synonyms:IL-3Rα; IL-3 Receptor alpha;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P26951
Gene ID:3563
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.

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