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PE Anti-Human CD123 Antibody [6H6] (AGEL1456)

SKU:
AGEL1456
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€129 - €389
Frequently bought together:

Description

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PE Anti-Human CD123 Antibody [6H6]

The Human CD123 Monoclonal Antibody (PE-conjugated, 6H6, AGEL1456) offered by AssayGenie is a cutting-edge tool for researchers studying CD123, a cell surface marker associated with various hematological malignancies. With a specific binding capacity to human CD123, this monoclonal antibody is designed for flow cytometry applications, enabling precise identification and characterization of CD123-expressing cells in research settings.CD123, also known as interleukin-3 receptor alpha chain, is a critical biomarker widely studied in the context of hematopoietic disorders such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Its overexpression has been linked to disease progression and poor prognosis in certain malignancies, making it a target of interest for therapeutic interventions and prognostic assessments.

By utilizing the Human CD123 Monoclonal Antibody (PE-conjugated, 6H6, AGEL1456), researchers can accurately profile and quantify CD123-positive cell populations in biological samples, facilitating the advancement of studies in cancer biology, immunotherapy, and targeted treatment strategies. This antibody provides a reliable tool for unraveling the complexities of CD123 biology and its implications in hematological malignancies, paving the way for innovative research discoveries and potential clinical applications.

Product Title:PE Anti-Human CD123 Antibody [6H6]
SKU:AGEL1456
Size:20 Tests, 100 Tests, 200 Tests
Clone No:6H6
Synonyms:IL-3Rα; IL-3 Receptor alpha;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P26951
Gene ID:3563
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.

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