null

FITC Anti-Human CD107a/LAMP-1 Antibody [H4A3] (AGEL1774)

SKU:
AGEL1774
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$227 - $755
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

FITC Anti-Human CD107a/LAMP-1 Antibody [H4A3]

The Human CD107a (LAMP-1) Monoclonal Antibody (FITC Conjugated) - H4A3 (AGEL1774) is a powerful tool for researchers studying cell biology and immunology. This monoclonal antibody is specifically designed to target CD107a, also known as Lysosomal-Associated Membrane Protein 1 (LAMP-1), a key marker of lysosomal compartments and cytotoxic granules in human cells.By utilizing this antibody, researchers can effectively detect and analyze CD107a expression in a variety of cell types, providing valuable insights into cellular processes related to lysosomal trafficking, exocytosis, and immune responses. The FITC conjugation allows for easy and efficient visualization of CD107a-positive cells using flow cytometry or fluorescence microscopy techniques.

The significance of CD107a in cell biology and immunology research makes this monoclonal antibody an essential tool for investigating lysosomal function, cytotoxicity, and immune cell activation. Its high specificity and reactivity with human samples ensure reliable and reproducible results, advancing our understanding of cellular mechanisms involved in immune surveillance and host defense.Whether studying immune cell interactions, cytotoxicity assays, or lysosomal dynamics, the Human CD107a Monoclonal Antibody (FITC Conjugated) - H4A3 (AGEL1774) offers a versatile and reliable solution for researchers looking to unravel the complexities of cellular processes at the intersection of lysosomal biology and immune function.

Product Title:FITC Anti-Human CD107a/LAMP-1 Antibody [H4A3]
SKU:AGEL1774
Size:20 Tests, 100 Tests, 200 Tests
Clone No:H4A3
Synonyms:Lysosome-Associated Membrane Protein 1; LGP-120; LAMP-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:FITC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11279
Gene ID:3916
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Related Products