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APC Anti-Human CD107a/LAMP-1 Antibody [H4A3] (AGEL1776)

SKU:
AGEL1776
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€219 - €769
Frequently bought together:

Description

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APC Anti-Human CD107a/LAMP-1 Antibody [H4A3]

The Human CD107a (LAMP-1) Monoclonal Antibody (APC Conjugated), H4A3, (AGEL1776) is a cutting-edge tool designed for research involving the CD107a protein, a critical marker of lysosomal activity and immune cell degranulation. This monoclonal antibody, conjugated with APC for enhanced detection capabilities, is specifically tailored for use in flow cytometry applications to study lysosomal trafficking and exocytosis in human samples. It binds specifically to the CD107a protein, allowing for precise detection and analysis in various cell types, making it an ideal choice for investigations in immunology, virology, and cellular biology.The CD107a protein, also known as Lysosomal-Associated Membrane Protein 1 (LAMP-1), plays a pivotal role in cellular processes such as phagocytosis, antigen presentation, and vesicular trafficking.

Its involvement in immune response modulation and cytotoxic activity highlights its importance in understanding host defense mechanisms and inflammatory responses. Research utilizing this antibody may provide crucial insights into immune cell function, particularly in the context of infectious diseases, cancer immunology, and autoimmune disorders.Unlock the potential of your research with the Human CD107a (LAMP-1) Monoclonal Antibody (APC Conjugated), H4A3, (AGEL1776) and delve deeper into the intricate mechanisms governing immune cell activation and effector functions.

Product Title:APC Anti-Human CD107a/LAMP-1 Antibody [H4A3]
SKU:AGEL1776
Size:20 Tests, 100 Tests, 200 Tests
Clone No:H4A3
Synonyms:Lysosome-Associated Membrane Protein 1; LGP-120; LAMP-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11279
Gene ID:3916
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

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