Human CCNA2 Recombinant Protein (RPPB2450)
- SKU:
- RPPB2450
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20248
- Research Area:
- Enzymes
Description
| Product Name: | Human CCNA2 Recombinant Protein |
| Product Code: | RPPB2450 |
| Size: | 20µg |
| Species: | Human |
| Target: | CCNA2 |
| Synonyms: | Cyclin-A2, Cyclin-A, CCNA2, CCN1, CCNA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | CCNA2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMLGNSA PGPATREAGS ALLALQQTAL QEDQENINPE KAAPVQQPRT RAALAVLKSG NPRGLAQQQR PKTRRVAPLK DLPVNDEHVT VPPWKANSKQ PAFTIHVDEA EKEAQKKPAE SQKIEREDAL AFNSAISLPG PRKPLVPLDY PMDGSFESPHTMDMSIVLED EKPVSVNEVP DYHEDIHTYL REMEVKCKPK VGYMKKQPDI TNSMRAILVD WLVEVGEEYK LQNETLHLAV NYIDRFLSSM SVLRGKLQLV GTAAMLLASK FEEIYPPEVA EFVYITDDTY TKKQVLRMEH LVLKVLTFDL AAPTVNQFLT QYFLHQQPAN CKVESLAMFLGELSLIDADP YLKYLPSVIA GAAFHLALYT VTGQSWPESL IRKTGYTLES LKPCLMDLHQ TYLKAPQHAQ QSIREKYKNS KYHGVSLLNP PETLNL |
CCNA2 is a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins act as regulators of CDK kinases. Various cyclins demonstrate distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Contrary to cyclin A1, which is present only in germ cells, CCNA2 is expressed in all tissues tested. CCNA2 binds and activates CDC2 or CDK2 kinases, and consequently promotes both cell cycle G1/S and G2/M transitions.
CCNA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-432 a.a) and having a molecular mass of 51.1kDa.CCNA2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCNA2: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 4q27 Cellular Component: nucleoplasm; male pronucleus; cytoplasm; female pronucleus; nucleus Molecular Function:protein binding; protein kinase binding Biological Process: mitosis; positive regulation of fibroblast proliferation; organ regeneration; response to glucagon stimulus; cell division; positive regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; regulation of G2/M transition of mitotic cell cycle; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; response to estradiol stimulus |
| NCBI Summary: | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016] |
| UniProt Code: | P20248 |
| NCBI GenInfo Identifier: | 311033358 |
| NCBI Gene ID: | 890 |
| NCBI Accession: | P20248.2 |
| UniProt Related Accession: | P20248 |
| Molecular Weight: | ~ 49kDa |
| NCBI Full Name: | Cyclin-A2 |
| NCBI Synonym Full Names: | cyclin A2 |
| NCBI Official Symbol: | CCNA2�� |
| NCBI Official Synonym Symbols: | CCN1; CCNA�� |
| NCBI Protein Information: | cyclin-A2 |
| UniProt Protein Name: | Cyclin-A2 |
| Protein Family: | Protein |
| UniProt Gene Name: | CCNA2�� |
| UniProt Entry Name: | CCNA2_HUMAN |
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