Human CCL3L1 Recombinant Protein (RPPB1110)
- SKU:
- RPPB1110
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P16619
- Research Area:
- Chemokines
Description
| Product Name: | Human CCL3L1 Recombinant Protein |
| Product Code: | RPPB1110 |
| Size: | 20µg |
| Species: | Human |
| Target: | CCL3L1 |
| Synonyms: | C-C motif chemokine 3-like 1, G0/G1 switch regulatory protein 19-2, LD78-beta(1-70), PAT 464.2, Small-inducible cytokine A3-like 1, Tonsillar lymphocyte LD78 beta protein, CCL3L1, D17S1718, G0S19-2, SCYA3L1, LD78, 464.2, SCYA3L, LD78BETA, MGC12815. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in 1xPBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized CCL3L1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CCL3L1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL3L1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA |
| Biological Activity: | The biological activity was determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml. |
CCL3L1 is a small cytokine that belongs to the CC chemokines. The CCL3L1 gene is one of several cytokine genes clustered on the q-arm of chromosome 17. CCL3L1 is involved in immunoregulatory and inflammatory processes. CCL3L1 binds to several chemokine receptors including CCBP2 and CCR5. CCR5 is a co-receptor for HIV, and binding of the CCL3L1 protein to CCR5 inhibits HIV entry.
CCL3L1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.7kDa. The CCL3L1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity Biological Process: negative regulation of cell proliferation; immune response; inflammatory response Disease: Human Immunodeficiency Virus Type 1, Susceptibility To |
| NCBI Summary: | This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014] |
| UniProt Code: | P16619 |
| NCBI GenInfo Identifier: | 127077 |
| NCBI Gene ID: | 414062 |
| NCBI Accession: | P16619.1 |
| UniProt Secondary Accession: | P16619,Q3B7A8, Q53YA5, Q96I68, A6NGK6, B2RUX4, |
| UniProt Related Accession: | P16619 |
| Molecular Weight: | 93 |
| NCBI Full Name: | C-C motif chemokine 3-like 1 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 3-like 3 |
| NCBI Official Symbol: | CCL3L3�� |
| NCBI Official Synonym Symbols: | LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA�� |
| NCBI Protein Information: | C-C motif chemokine 3-like 1; LD78-beta(1-70); small inducible cytokine A3-like 1; G0/G1 switch regulatory protein 19-2; tonsillar lymphocyte LD78 beta protein; chemokine (C-C motif) ligand 3-like, centromeric |
| UniProt Protein Name: | C-C motif chemokine 3-like 1 |
| UniProt Synonym Protein Names: | G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta proteinCleaved into the following 2 chains:LD78-beta(3-70); LD78-beta(5-70) |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL3L1�� |
| UniProt Entry Name: | CL3L1_HUMAN |
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