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Human CCL3L1 Recombinant Protein (RPPB1109)

SKU:
RPPB1109
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P16619
Research Area:
Chemokines
€309
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Description

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Product Name:Human CCL3L1 Recombinant Protein
Product Code:RPPB1109
Size:20µg
Species:Human
Target:CCL3L1
Synonyms:C-C motif chemokine 3-like 1, G0/G1 switch regulatory protein 19-2, LD78-beta(1-70), PAT 464.2, Small-inducible cytokine A3-like 1, Tonsillar lymphocyte LD78 beta protein, CCL3L1, D17S1718, G0S19-2, SCYA3L1, LD78, 464.2, SCYA3L, LD78BETA, MGC12815.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CCL3L1 solution (0.25 mg/ml) contains Phosphate Buffered Saline pH7.4 containing 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA

CCL3L1 is a small cytokine that belongs to the CC chemokines. The CCL3L1 gene is one of several cytokine genes clustered on the q-arm of chromosome 17. CCL3L1 is involved in immunoregulatory and inflammatory processes. CCL3L1 binds to several chemokine receptors including CCBP2 and CCR5. CCR5 is a co-receptor for HIV, and binding of the CCL3L1 protein to CCR5 inhibits HIV entry.

CCL3L1 Human Recombinant fused with a 22 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 90 amino acids (26-93 a.a.) and having a molecular mass of 10kDa. The CCL3L1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular space; extracellular region

Molecular Function:chemokine activity

Biological Process: negative regulation of cell proliferation; immune response; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

NCBI Summary:This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]
UniProt Code:P16619
NCBI GenInfo Identifier:127077
NCBI Gene ID:414062
NCBI Accession:P16619.1
UniProt Secondary Accession:P16619,Q3B7A8, Q53YA5, Q96I68, A6NGK6, B2RUX4,
UniProt Related Accession:P16619
Molecular Weight:93
NCBI Full Name:C-C motif chemokine 3-like 1
NCBI Synonym Full Names:chemokine (C-C motif) ligand 3-like 3
NCBI Official Symbol:CCL3L3��
NCBI Official Synonym Symbols:LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA��
NCBI Protein Information:C-C motif chemokine 3-like 1; LD78-beta(1-70); small inducible cytokine A3-like 1; G0/G1 switch regulatory protein 19-2; tonsillar lymphocyte LD78 beta protein; chemokine (C-C motif) ligand 3-like, centromeric
UniProt Protein Name:C-C motif chemokine 3-like 1
UniProt Synonym Protein Names:G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta proteinCleaved into the following 2 chains:LD78-beta(3-70); LD78-beta(5-70)
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL3L1��
UniProt Entry Name:CL3L1_HUMAN

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