Human CASR-Strep full length protein-synthetic nanodisc (HDFP945)
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- SKU:
- HDFP945
- Size:
- 10μg
- Target:
- CASR
- Tag:
- C-Flag&Strep Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
Description
| Product Name: | Nanodisc Human CASR-Strep Protein |
| SKU: | HDFP945 |
| Size: | 10μg |
| Target: | CASR |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human CASR-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | GPCRDB Class C Metabotropic glutamate pheromone, Apoptosis, G-Protein Coupled Receptors Signaling Pathway, Osteogenesis. |
| Molecular Weight: | The human full length CASR-Strep protein has a MW of 120.7 kDa |
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
| Uniprot ID: | P41180 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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