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Human CARD18 Recombinant Protein (RPPB2984)

SKU:
RPPB2984
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P57730
€309
Frequently bought together:

Description

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Product Name:Human CARD18 Recombinant Protein
Product Code:RPPB2984
Size:10µg
Species:Human
Target:CARD18
Synonyms:Caspase recruitment domain family member 18, ICEBERG, pseudo-ICE, UNQ5804, Caspase-1 inhibitor Iceberg, ICEBERG caspase-1 inhibitor.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The LSM3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH

CARD18 belongs to the death-domain-fold superfamily which is induced by proinflammatory stimuli. CARD18 contains basically only a Caspase recruitment domain, inhibits generation of IL-1b by cooperating with caspase-1 and inhibiting connotation with RIP 2. The connotation of CARD18 to caspase-1 is enabled by the charge-charge interactions between the prodomain of caspase-1 and the surface charge of CARD18.

CARD18 Human Recombinant produced in�E. coli is a single polypeptide chain containing 110 amino acids (1-90) and having a molecular mass of 12.3kDa.CARD18 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P57730
NCBI GenInfo Identifier:10954343
NCBI Gene ID:59082
NCBI Accession:NP_067546.1
UniProt Secondary Accession:P57730,A2RRF8
UniProt Related Accession:P57730
Molecular Weight:10,138 Da
NCBI Full Name:caspase recruitment domain-containing protein 18
NCBI Synonym Full Names:caspase recruitment domain family member 18
NCBI Official Symbol:CARD18��
NCBI Official Synonym Symbols:ICEBERG; UNQ5804; pseudo-ICE��
NCBI Protein Information:caspase recruitment domain-containing protein 18
UniProt Protein Name:Caspase recruitment domain-containing protein 18
UniProt Synonym Protein Names:Caspase-1 inhibitor Iceberg
Protein Family:
UniProt Gene Name:CARD18��
UniProt Entry Name:CAR18_HUMAN

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