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Human CAPZA2 Recombinant Protein (RPPB2982)

SKU:
RPPB2982
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P47755
$371
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Description

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Product Name:Human CAPZA2 Recombinant Protein
Product Code:RPPB2982
Size:20µg
Species:Human
Target:CAPZA2
Synonyms:Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2, F-Actin Capping Protein Alpha-2 Subunit, CapZ Alpha-2, CAPPA, CAPZ2, F-Actin-Capping Protein Subunit Alpha-2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CAPZA2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, and 0.4M UREA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMADLEEQ LSDEEKVRIA AKFIIHAPPG EFNEVFNDVR LLLNNDNLLR EGAAHAFAQY NLDQFTPVKI EGYEDQVLIT EHGDLGNGKF LDPKNRICFK FDHLRKEATD PRPCEVENAV ESWRTSVETA LRAYVKEHYP NGVCTVYGKK IDGQQTIIAC IESHQFQAKN FWNGRWRSEW KFTITPSTTQ VVGILKIQVH YYEDGNVQLV SHKDIQDSLT VSNEVQTAKE FIKIVEAAEN EYQTAISENY QTMSDTTFKA LRRQLPVTRT KIDWNKILSY KIGKEMQNA

Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2 also known as CAPZA2 belongs the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. Among the diseases associated with CAPZA2 are endocarditis, and cervicitis.

CAPZA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (1-286 a.a) and having a molecular mass of 35.3kDa.CAPZA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CAPZA2: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Belongs to the F-actin-capping protein alpha subunit family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q31.2-q31.3

Cellular Component: cortical cytoskeleton; F-actin capping protein complex; membrane; extracellular region; cytosol; actin cytoskeleton

Molecular Function:actin binding

Biological Process: innate immune response; protein complex assembly; cell motility; barbed-end actin filament capping; blood coagulation

NCBI Summary:The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
UniProt Code:P47755
NCBI GenInfo Identifier:1345695
NCBI Gene ID:830
NCBI Accession:P47755.3
UniProt Secondary Accession:P47755,B4DG50,
UniProt Related Accession:P47755
Molecular Weight:286
NCBI Full Name:F-actin-capping protein subunit alpha-2
NCBI Synonym Full Names:capping protein (actin filament) muscle Z-line, alpha 2
NCBI Official Symbol:CAPZA2��
NCBI Official Synonym Symbols:CAPZ; CAPPA2��
NCBI Protein Information:F-actin-capping protein subunit alpha-2; capZ alpha-2; F-actin capping protein alpha-2 subunit
UniProt Protein Name:F-actin-capping protein subunit alpha-2
UniProt Synonym Protein Names:CapZ alpha-2
Protein Family:F-actin-capping protein
UniProt Gene Name:CAPZA2��
UniProt Entry Name:CAZA2_HUMAN

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