Human CAMP Recombinant Protein (RPPB2975)
- SKU:
- RPPB2975
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49913
Description
| Product Name: | Human CAMP Recombinant Protein |
| Product Code: | RPPB2975 |
| Size: | 10µg |
| Species: | Human |
| Target: | CAMP |
| Synonyms: | CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26, LL37, 18 kDa cationic antimicrobial protein, FALL-39 peptide antibiotic, Cathelicidin antimicrobial peptide. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CAMP protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSQVLSYKE AVLRAIDGIN QRSSDANLYR LLDLDPRPTM DGDPDTPKPV SFTVKETVCP RTTQQSPEDC DFKKDGLVKR CMGTVTLNQA RGSFDISCDK DNKRFALLGD FFRKSKEKIG KEFKRIVQRI KDFLRNLVPR TES |
CAMP belongs to the antimicrobial peptide family, contains highly conserved N-terminal signal peptide, a cathelin domain and a structurally variable cationic antimicrobial peptide that produced by extracellular proteolysis from the C-terminus. CAMP has numerous functions besides the antimicrobial activity such as: cell chemotaxis, immune mediator induction and inflammatory response regulation.
CAMP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (34-173 a.a.) and having a molecular mass of 18.4kDa.CAMP is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | CAMP: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Belongs to the cathelicidin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cell cycle regulation; Vesicle; Secreted Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: cell wall; extracellular region; extracellular space; specific granule Biological Process: antibacterial humoral response; cell redox homeostasis; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response in mucosa; killing by host of symbiont cells |
| NCBI Summary: | This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P49913 |
| NCBI GenInfo Identifier: | 1706745 |
| NCBI Gene ID: | 820 |
| NCBI Accession: | P49913.1 |
| UniProt Secondary Accession: | P49913,Q71SN9, |
| UniProt Related Accession: | P49913 |
| Molecular Weight: | 19,301 Da |
| NCBI Full Name: | Cathelicidin antimicrobial peptide |
| NCBI Synonym Full Names: | cathelicidin antimicrobial peptide |
| NCBI Official Symbol: | CAMP�� |
| NCBI Official Synonym Symbols: | LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39�� |
| NCBI Protein Information: | cathelicidin antimicrobial peptide |
| UniProt Protein Name: | Cathelicidin antimicrobial peptide |
| UniProt Synonym Protein Names: | FALL-39 peptide antibiotic |
| Protein Family: | CAMPATH-1 antigen |
| UniProt Gene Name: | CAMP�� |
| UniProt Entry Name: | CAMP_HUMAN |
| Marina Garcia-Moreno et al. | Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms | Frontiers in Microbiology 2022 | PubMed ID: 35935196 |
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