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Human CAMK4 Recombinant Protein (RPPB2447)

SKU:
RPPB2447
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16566
Research Area:
Enzymes
$371
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Description

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Product Name:Human CAMK4 Recombinant Protein
Product Code:RPPB2447
Size:10µg
Species:Human
Target:CAMK4
Synonyms:Calcium/calmodulin-dependent protein kinase type IV catalytic chain, CaMK-GR, CaM kinase-GR, CaMK IV, IV, brain Ca(2+)-calmodulin-dependent protein kinase type IV, caMK, CAM kinase IV, EC 2.7.11.17.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CAMK4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMLKVTV PSCSASSCSS VTASAAPGTA SLVPDYWIDG SNRDALSDFF EVESELGRGA TSIVYRCKQK GTQKPYALKV LKKTVDKKIV RTEIGVLLRL SHPNIIKLKE IFETPTEISL VLELVTGGEL FDRIVEKGYY SERDAADAVK QILEAVAYLH ENGIVHRDLK PENLLYATPA PDAPLKIADF GLSKIVEHQV LMKTVCGTPG YCAPEILRGC AYGPEVDMWS VGIITYILLC GFEPFYDERG DQFMFRRILN CEYYFISPWW DEVSLNAKDL VRKLIVLDPK KRLTTFQALQ HPWVTGKAAN FVHMDTAQKK LQEFNARRKL KAAVKAVVAS SRLGSASSSH GSIQESHKAS RDPSPIQDGN EDMKAIPEGE KIQGDGAQAA VKGAQAELMK VQALEKVKGA DINAEEAPKM VPKAVEDGIK VADLELEEGL AEEKLKTVEE AAAPREGQGS SAVGFEVPQQ DVILPEY

CAMK4 is a member of the serine/threonine protein kinase family, and of the Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK4 is a multifunctional serine/threonine protein kinase with restricted tissue distribution which is associated to transcriptional regulation in lymphocytes, neurons and male germ cells.

CAMK4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 497 amino acids (1-473) and having a molecular mass of 54.5kDa.CAMK4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CAMK4: a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; Kinase, protein; CAMK group; CAMK1 family

Chromosomal Location of Human Ortholog: 5q21.3

Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm

Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity

Biological Process: adaptive immune response; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; long-term memory; myeloid dendritic cell cytokine production; myeloid dendritic cell differentiation; nerve growth factor receptor signaling pathway; nerve-nerve synaptic transmission; nucleocytoplasmic transport; peptidyl-serine phosphorylation; phospholipase C activation; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of osteoclast differentiation; regulation of T cell differentiation in the thymus; signal transduction; synaptic transmission

NCBI Summary:The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q16566
NCBI GenInfo Identifier:2499586
NCBI Gene ID:814
NCBI Accession:Q16566.1
UniProt Secondary Accession:Q16566,D3DSZ7,
UniProt Related Accession:Q16566
Molecular Weight:51,926 Da
NCBI Full Name:Calcium/calmodulin-dependent protein kinase type IV
NCBI Synonym Full Names:calcium/calmodulin-dependent protein kinase IV
NCBI Official Symbol:CAMK4��
NCBI Official Synonym Symbols:caMK; CaMK IV; CaMK-GR��
NCBI Protein Information:calcium/calmodulin-dependent protein kinase type IV
UniProt Protein Name:Calcium/calmodulin-dependent protein kinase type IV
UniProt Synonym Protein Names:CaM kinase-GR
Protein Family:Calcium/calmodulin-dependent protein kinase
UniProt Gene Name:CAMK4��
UniProt Entry Name:KCC4_HUMAN

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