Human CA11 Recombinant Protein (RPPB1464)
- SKU:
- RPPB1464
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75493
- Research Area:
- Enzymes
Description
| Product Name: | Human CA11 Recombinant Protein |
| Product Code: | RPPB1464 |
| Size: | 20µg |
| Species: | Human |
| Target: | CA11 |
| Synonyms: | Carbonic Anhydrase XI, Carbonic Anhydrase-Related Protein 2, Carbonic Anhydrase-Related Protein 11, CARP-2, CA-RP II, CARP XI, CARPX1, CA-XI. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The CA11 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MHIGPAPDPE DWWSYKDNLQ GNFVPGPPFW GLVNAAWSLC AVGKRQSPVD VELKRVLYDP FLPPLRLSTG GEKLRGTLYN TGRHVSFLPA PRPVVNVSGG PLLYSHRLSE LRLLFGARDG AGSEHQINHQ GFSAEVQLIH FNQELYGNFS AASRGPNGLA ILSLFVNVAS TSNPFLSRLL NRDTITRISY KNDAYFLQDL SLELLFPESF GFITYQGSLS TPPCSETVTW ILIDRALNIT SLQMHSLRLL SQNPPSQIFQ SLSGNSRPLQ PLAHRALRGN RDPRHPERRC RGPNYRLHVD GVPHGR |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. These metalloenzymes participate in various biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. The metalloenzymes exhibit extensive diversity in tissue distribution and in their subcellular localization. Carbonic Anhydrase XI (CA11) is probably a secreted protein, nevertheless, drastic changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that CA11 has carbonic anhydrase activity. CA11 shares properties in common with 2 other acatalytic CA isoforms, CA VIII and CA X. CA11 is amply expressed in the brain, and may have a general role in the central nervous system.
CA11 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 326 amino acids (24-328) and having a molecular mass of 36.3kDa.CA11 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Does not have a catalytic activity. |
| UniProt Protein Details: | |
| NCBI Summary: | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75493 |
| NCBI GenInfo Identifier: | 9951923 |
| NCBI Gene ID: | 770 |
| NCBI Accession: | NP_001208.2 |
| UniProt Secondary Accession: | O75493,O60596, Q6FHI1, Q9UEC4 |
| UniProt Related Accession: | O75493 |
| Molecular Weight: | Molecular Mass: 35.1 kDaActual Protein Molecular Mass: 38 kDa |
| NCBI Full Name: | carbonic anhydrase-related protein 11 |
| NCBI Synonym Full Names: | carbonic anhydrase 11 |
| NCBI Official Symbol: | CA11�� |
| NCBI Official Synonym Symbols: | CA-RP; CA-XI; CARP-2; CARPX1; CA-RP II�� |
| NCBI Protein Information: | carbonic anhydrase-related protein 11 |
| UniProt Protein Name: | Carbonic anhydrase-related protein 11 |
| UniProt Synonym Protein Names: | CA-RP XI; CA-XI; CARP XI; Carbonic anhydrase-related protein 2; CA-RP II; CARP-2 |
| Protein Family: | Carbonic anhydrase-related protein |
| UniProt Gene Name: | CA11�� |
| UniProt Entry Name: |
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