Human C6ORF108 Recombinant Protein (RPPB2952)
- SKU:
- RPPB2952
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43598
Description
| Product Name: | Human C6ORF108 Recombinant Protein |
| Product Code: | RPPB2952 |
| Size: | 25µg |
| Species: | Human |
| Target: | C6ORF108 |
| Synonyms: | c-Myc-responsive protein Rcl, RCL,putative c-Myc-responsive. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The C6ORF108 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH-8), 1mM DTT, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAAMVPGRS ESWERGEPGR PALYFCGSIR GGREDRTLYE RIVSRLRRFG TVLTEHVAAA ELGARGEEAAGGDRLIHEQD LEWLQQADVV VAEVTQPSLG VGYELGRAVA FNKRILCLFR PQSGRVLSAM IRGAADGSRF QVWDYEEGEV EALLDRYFEA DPPGQVAASP DPTT |
C6ORF108 is stimulated by c-Myc protein that is a transcription factor that is involved in the regulation of cell proliferation, differentiation, and apoptosis. C6ORF108 functions in rat in cellular proliferation and c-Myc-mediated transformation. C6ORF108 catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5''-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5''-monophosphates comprising purine bases are favored to those comprising of pyrimidine bases.
C6ORF108 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 194 amino acids (1-174 a.a.) and having a molecular mass of 21.2kDa.C6ORF108 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DNPH1: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. Monomer and homodimer. Expression is induced by ETV1. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. Belongs to the deoxyribonucleoside 5'-monophosphate N- glycosidase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.2.2.-; Hydrolase Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein homodimerization activity; nucleoside deoxyribosyltransferase activity Biological Process: cell proliferation; epithelial cell differentiation; nucleoside metabolic process; nucleotide metabolic process; positive regulation of cell growth; deoxyribonucleoside monophosphate catabolic process |
| NCBI Summary: | This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43598 |
| NCBI GenInfo Identifier: | 5454002 |
| NCBI Gene ID: | 10591 |
| NCBI Accession: | NP_006434.1 |
| UniProt Secondary Accession: | O43598,Q80VJ3, O35820, |
| UniProt Related Accession: | O43598 |
| Molecular Weight: | 19,108 Da |
| NCBI Full Name: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1 |
| NCBI Synonym Full Names: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
| NCBI Official Symbol: | DNPH1�� |
| NCBI Official Synonym Symbols: | RCL; C6orf108; dJ330M21.3; RP3-330M21.3�� |
| NCBI Protein Information: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; putative c-Myc-responsive; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase |
| UniProt Protein Name: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
| UniProt Synonym Protein Names: | c-Myc-responsive protein RCL |
| UniProt Gene Name: | DNPH1�� |
| UniProt Entry Name: | DNPH1_HUMAN |
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