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Human C1GALT1 Recombinant Protein (RPPB1454)

SKU:
RPPB1454
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NS00
Research Area:
Enzymes
€309
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Description

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Product Name:Human C1GALT1 Recombinant Protein
Product Code:RPPB1454
Size:10µg
Species:Human
Target:C1GALT1
Synonyms:Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine3-Beta-Galactosyltransferase 1, Core 1 Beta3-Gal-T1, Core 1 O-Glycan T-Synthase,Core 1 UDP-Galactose:N-Acetylgalactosamine-Alpha-R Beta 1,3 Galactosyltransferase1, B3Gal-T8, EC 2.4.1.122, Core 1 Beta3-Gal-T, C1GALT, T-synthase, Glycoprotein-N-Acetylgalactosamine3-Beta-Galactosyltransferase 1, Beta-1,3-galactosyltransferase, C1GalT1, Core 1Beta1,3-Galactosyltransferase 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:C1GALT1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLLGEKVD TQPNVLHNDP HARHSDDNGQ NHLEGQMNFN ADSSQHKDEN TDIAENLYQK VRILCWVMTG PQNLEKKAKH VKATWAQRCN KVLFMSSEEN KDFPAVGLKT KEGRDQLYWK TIKAFQYVHE HYLEDADWFL KADDDTYVIL DNLRWLLSKY DPEEPIYFGR RFKPYVKQGY MSGGAGYVLS KEALKRFVDA FKTDKCTHSS SIEDLALGRC MEIMNVEAGD SRDTIGKETF HPFVPEHHLI KGYLPRTFWY WNYNYYPPVE GPGCCSDLAV SFHYVDSTTM YELEYLVYHL RPYGYLYRYQ PTLPERILKE ISQANKNEDT KVKLGNP

Core1 Beta3-Gal-T1 also known as, C1GALT1 creates the common core 1 O-glycanstructure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal toGalNAc-alpha-1-R. Core 1 is a precursor for lots of extended mucin-typeO-glycans on cell surfaceand secreted glycoproteins. Studies in mice have shown that this gene takes amain role in angiogenesis, thrombopoiesis and kidney homeostasis.

C1GALT1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (30-363 a.a) and having a molecular mass of 41.4kDa.C1GALT1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:C1GALT1: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.4.1.122; Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: Golgi membrane; integral to membrane

Molecular Function:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; protein binding

Biological Process: angiogenesis; kidney development; O-glycan processing; O-glycan processing, core 1

NCBI Summary:The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]
UniProt Code:Q9NS00
NCBI GenInfo Identifier:74719147
NCBI Gene ID:56913
NCBI Accession:Q9NS00.1
UniProt Secondary Accession:Q9NS00,Q96QH4, Q9BTU1,
UniProt Related Accession:Q9NS00
Molecular Weight:35,935 Da
NCBI Full Name:Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
NCBI Synonym Full Names:core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
NCBI Official Symbol:C1GALT1��
NCBI Official Synonym Symbols:C1GALT; T-synthase��
NCBI Protein Information:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
UniProt Protein Name:Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
UniProt Synonym Protein Names:B3Gal-T8; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1
Protein Family:C1GALT1-specific chaperone
UniProt Gene Name:C1GALT1��
UniProt Entry Name:C1GLT_HUMAN

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