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Human C1D Recombinant Protein (RPPB2937)

SKU:
RPPB2937
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q13901
€309
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Description

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Product Name:Human C1D Recombinant Protein
Product Code:RPPB2937
Size:10µg
Species:Human
Target:C1D
Synonyms:hC1D, LRP1, SUN-CoR, SUNCOR, Nuclear nucleic acid-binding protein C1D, C1D.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The C1D solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAGEEIN EDYPVEIHEY LSAFENSIGA VDEMLKTMMS VSRNELLQKL DPLEQAKVDL VSAYTLNSMF WVYLATQGVN PKEHPVKQEL ERIRVYMNRV KEITDKKKAG KLDRGAASRF VKNALWEPKS KNASKVANKG KSKS

C1D s which regulates TRAX/Translin complex formation takes part in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA. C1D which activates PRKDC in the presence of linear DNA and supercoiled DNA also induces apoptosis in a p53/TP53 dependent manner.

C1D Human Recombinant produced in E. coli is a single polypeptide chain containing 164 amino acids (1-141) and having a molecular mass of 18.4kDa. C1D is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.
UniProt Protein Details:

Protein type:Nucleolus; DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2p13-p12

Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex)

Molecular Function:ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity

Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
UniProt Code:Q13901
NCBI GenInfo Identifier:74754472
NCBI Gene ID:10438
NCBI Accession:Q13901.1
UniProt Secondary Accession:Q13901,Q05D64, A8K336, D6W5F8,
UniProt Related Accession:Q13901
Molecular Weight:141
NCBI Full Name:Nuclear nucleic acid-binding protein C1D
NCBI Synonym Full Names:C1D nuclear receptor corepressor
NCBI Official Symbol:C1D��
NCBI Official Synonym Symbols:LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR��
NCBI Protein Information:nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor
UniProt Protein Name:Nuclear nucleic acid-binding protein C1D
Protein Family:Nuclear nucleic acid-binding protein
UniProt Gene Name:C1D��
UniProt Entry Name:C1D_HUMAN

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