Human BMP8B Recombinant Protein (RPPB0106)
- SKU:
- RPPB0106
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P34820
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human BMP8B Recombinant Protein |
| Product Code: | RPPB0106 |
| Size: | 20µg |
| Species: | Human |
| Target: | BMP8B |
| Synonyms: | Bone morphogenetic protein 8B, BMP-8, BMP-8B, Osteogenic protein 2, OP-2, BMP8B, BMP8, Bone Morphogenetic protein-8b, OP2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | BMP8B protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH |
Bone Morphogenetic protein-8b (BMP8B) belongs to a family of secreted signaling molecules which can induce ectopic bone growth. BMP8B is known for having a possible bone inductive activity as it is related to BMP5 and BMP7. BMP8B is the osteoinductive factor accountable for epithelial osteogenesis.
BMP8B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 162 amino acids (264-402a.a.) and having a molecular mass of 18.1kDa.BMP8B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BMP8B: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Belongs to the TGF-beta family.Protein type: Secreted; Secreted, signal peptide; CytokineChromosomal Location of Human Ortholog: 1p35-p32Cellular Component: extracellular spaceMolecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor bindingBiological Process: BMP signaling pathway; cartilage development; cell development; growth; ossification; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P34820 |
| NCBI GenInfo Identifier: | 7018292 |
| NCBI Gene ID: | |
| NCBI Accession: | CAB75681 |
| UniProt Secondary Accession: | P34820,Q32NE5, Q53ZM7, Q9NUF0, E7EMY8 |
| UniProt Related Accession: | P34820 |
| Molecular Weight: | 39,151 Da |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Bone morphogenetic protein 8B |
| UniProt Synonym Protein Names: | Osteogenic protein 2; OP-2 |
| Protein Family: | |
| UniProt Gene Name: | BMP8B�� |
| UniProt Entry Name: | BMP8B_HUMAN |
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