Human BMF Recombinant Protein (RPPB2900)
- SKU:
- RPPB2900
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96LC9
Description
| Product Name: | Human BMF Recombinant Protein |
| Product Code: | RPPB2900 |
| Size: | 20µg |
| Species: | Human |
| Target: | BMF |
| Synonyms: | Bcl-2-modifying factor, FLJ00065, BMF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The Bcl2 modifying factor solution contains 20mM Tris pH-7.5, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MASMTGGQQM GRGSHMEPSQ CVEELEDDVF QPEDGEPVTQ PGSLLSADLF AQSLLDCPLS RLQLFPLTHC CGPGLRPTSQ EDKATQTLSPASPSQGVMLP CGVTEEPQRL FYAPAEPKSC VVADPPLPAQ PCFEWRREQE RGRP |
Bcl2 modifying factor, is a member of the Bcl2 protein family of apoptosis mediators. Bcl2 modifying factor is widely expressed in many tissues. Bcl2 modifying factor contains a single Bcl2 homology domain 3 (BH3), and binds Bcl2 proteins and functions as an apoptotic activator. Also, Bcl2 modifying factor is important for histone deacetylase (HDAC) inhibitors which alters the balance between acetylation and deacetylation, significantly increasing histone acetylation, while strongly inducing apoptosis in a variety of cancer cell types. Bcl2 modifying factor supports Bim in regulating cell death processes in response to many stimuli. A synergistic role for bim and Bcl2 modifying factor in an apoptotic pathway leading to the clearance of Neisseria gonorrhoeae -infected cells.
Bcl2 modifying factor Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 144 amino acids (1-129 a.a.) and having a molecular mass of 15.6 kDa.The Bcl2 modifying factor is fused to 15 amino acid His Tag at Nterminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Cytoskeletal Chromosomal Location of Human Ortholog: 15q14 Cellular Component: mitochondrial outer membrane; plasma membrane; acrosome; cytosol; myosin complex Molecular Function:protein binding Biological Process: positive regulation of protein homooligomerization; apoptosis; anoikis |
| NCBI Summary: | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96LC9 |
| NCBI GenInfo Identifier: | 56748563 |
| NCBI Gene ID: | 90427 |
| NCBI Accession: | Q96LC9.1 |
| UniProt Secondary Accession: | Q96LC9,Q2M396, Q6NT30, Q6NT56, Q6P9F6, Q7Z7D4, Q7Z7D5 Q9H7K7, |
| UniProt Related Accession: | Q96LC9 |
| Molecular Weight: | 184 |
| NCBI Full Name: | Bcl-2-modifying factor |
| NCBI Synonym Full Names: | Bcl2 modifying factor |
| NCBI Official Symbol: | BMF�� |
| NCBI Protein Information: | bcl-2-modifying factor |
| UniProt Protein Name: | Bcl-2-modifying factor |
| Protein Family: | Bcl-2-modifying factor |
| UniProt Gene Name: | BMF�� |
| UniProt Entry Name: | BMF_HUMAN |
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