Human BLOC1S5 Recombinant Protein (RPPB5904)
- SKU:
- RPPB5904
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8TDH9
Description
| Product Name: | Human BLOC1S5 Recombinant Protein |
| Product Code: | RPPB5904 |
| Size: | 10µg |
| Species: | Human |
| Target: | BLOC1S5 |
| Synonyms: | Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | BLOC1S5 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 40% glycerol, 2mM DTT, 0.1mM PMSF and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSGGGTE TPVGCEAAPG GGSKKRDSLG TAGSAHLIIK DLGEIHSRLL DHRPVIQGET RYFVKEFEEK RGLREMRVLE NLKNMIHETN EHTLPKCRDT MRDSLSQVLQ RLQAANDSVC RLQQREQERK KIHSDHLVAS EKQHMLQWDN FMKEQPNKRA EVDEEHRKAM ERLKEQYAEM EKDLAKFSTF |
Muted homolog (MUTED) is a component of the BLOC-1 complex, a complex which is necessary for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. The BLOC-1 complex is needed to steer membrane protein cargos into vesicles assembled at cell bodies for release into neurites and nerve terminals. In addition, this complex, along with SNARE proteins, is suggested to be involved in neurite extension. MUTED also interacts with pallidin, dystrobrevin binding protein 1 and CNO/cappuccino. MUTED is ubiquitously expressed with higher levels in the brain, bone marrow, kidney, and liver and lower levels in the skeletal muscle.
BLOC1S5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-187 a.a) and having a molecular mass of 24kDa.BLOC1S5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q8TDH9 |
| NCBI GenInfo Identifier: | 313482848 |
| NCBI Gene ID: | 63915 |
| NCBI Accession: | NP_001186251.1 |
| UniProt Secondary Accession: | Q8TDH9,Q0VDJ6, Q0VDJ7, Q5THS1, Q68D56, Q8N5F9, Q9NU16 B4DVM2 |
| UniProt Related Accession: | Q8TDH9 |
| Molecular Weight: | 14,893 Da |
| NCBI Full Name: | biogenesis of lysosome-related organelles complex 1 subunit 5 isoform 2 |
| NCBI Synonym Full Names: | biogenesis of lysosomal organelles complex 1 subunit 5 |
| NCBI Official Symbol: | BLOC1S5�� |
| NCBI Official Synonym Symbols: | MU; BLOS5; MUTED�� |
| NCBI Protein Information: | biogenesis of lysosome-related organelles complex 1 subunit 5 |
| UniProt Protein Name: | Biogenesis of lysosome-related organelles complex 1 subunit 5 |
| UniProt Synonym Protein Names: | Protein Muted homolog |
| Protein Family: | |
| UniProt Gene Name: | BLOC1S5�� |
| UniProt Entry Name: |
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