Human BHMT2 Recombinant Protein (RPPB1444)
- SKU:
- RPPB1444
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H2M3
- Research Area:
- Enzymes
Description
| Product Name: | Human BHMT2 Recombinant Protein |
| Product Code: | RPPB1444 |
| Size: | 10µg |
| Species: | Human |
| Target: | BHMT2 |
| Synonyms: | BHMT2, Betaine--Homocysteine S-Methyltransferase 2, SMM-Hcy Methyltransferase, Betaine-Homocysteine Methyltransferase 2, S-Methylmethionine--Homocysteine S-Methyltransferase BHMT2, EC 2.1.1.10, EC 2.1.1.5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | BHMT2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAPAGRP GAKKGILERL ESGEVVIGDG SFLITLEKRG YVKAGLWTPE AVIEHPDAVR QLHMEFLRAG SNVMQTFTFS ASEDNMESKW EDVNAAACDL AREVAGKGDA LVAGGICQTS IYKYQKDEAR IKKLFRQQLE VFAWKNVDFL IAEYFEHVEE AVWAVEVLKE SDRPVAVTMC IGPEGDMHDI TPGECAVRLV KAGASIVGVN CRFGPDTSLK TMELMKEGLE WAGLKAHLMV QPLGFHAPDC GKEGFVDLPE YPFGLESRVA TRWDIQKYAR EAYNLGVRYI GGCCGFEPYH IRAIAEELAP ERGFLPPASE KHGSWGSGLD MHTKPWIRAR ARREYWENLL PASGRPFCPS LSKPDF |
Betaine-Homocysteine Methyltransferase 2 (BHMT2) is involved in the regulation of homocysteine metabolism. Homocysteine is a sulfur-containing amino acid which has a key role in methylation reactions. Transfer of the methyl group from betaine to homocysteine generates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. BHMT2 is one of two methyl transferases which can catalyze the transfer of the methyl group from betaine to homocysteine. BHMT2 converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. Homocysteine metabolism anomalies are implicated in disorders varying from vascular disease to neural tube birth defects such as spina bifida.
BHMT2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 386 amino acids (1-363 a.a.) and having a molecular mass of 42.7kDa. BHMT2 is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | BHMT2: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Methyltransferase; EC 2.1.1.10Chromosomal Location of Human Ortholog: 5q13Cellular Component: cytosolMolecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion bindingBiological Process: methylation; S-methylmethionine cycle; S-methylmethionine metabolic process; S-adenosylmethionine metabolic process; betaine metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9H2M3 |
| NCBI GenInfo Identifier: | 295821189 |
| NCBI Gene ID: | 23743 |
| NCBI Accession: | NP_001171476.1 |
| UniProt Secondary Accession: | Q9H2M3,Q9NXX7, B7Z516 |
| UniProt Related Accession: | Q9H2M3 |
| Molecular Weight: | 40,354 Da |
| NCBI Full Name: | S-methylmethionine--homocysteine S-methyltransferase BHMT2 isoform 2 |
| NCBI Synonym Full Names: | betaine--homocysteine S-methyltransferase 2 |
| NCBI Official Symbol: | BHMT2�� |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2 |
| UniProt Protein Name: | S-methylmethionine--homocysteine S-methyltransferase BHMT2 |
| UniProt Synonym Protein Names: | Betaine--homocysteine S-methyltransferase 2 |
| Protein Family: | S-methylmethionine--homocysteine S-methyltransferase |
| UniProt Gene Name: | BHMT2�� |
| UniProt Entry Name: | BHMT2_HUMAN |
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