Human BCL2L10 Recombinant Protein (RPPB2872)
- SKU:
- RPPB2872
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HD36
Description
| Product Name: | Human BCL2L10 Recombinant Protein |
| Product Code: | RPPB2872 |
| Size: | 20µg |
| Species: | Human |
| Target: | BCL2L10 |
| Synonyms: | Bcl-2-like protein 10, Bcl2-L-10, Anti-apoptotic protein NrH, Apoptosis regulator Bcl-B, BCL2L10, BCLB, Boo, Diva, BCL-B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | BCL2L10 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVDQLRE RTTMADPLRE RTELLLADYL GYCAREPGTP EPAPSTPEAA VLRSAAARLR QIHRSFFSAY LGYPGNRFEL VALMADSVLS DSPGPTWGRV VTLVTFAGTL LERGPLVTAR WKKWGFQPRL KEQEGDVARD CQRLVALLSS RLMGQHRAWL QAQGGWDGFC HFFRT |
BCL2 Like 10 (BCL2L10) is a member of the BCL-2 protein family. BCL2 family members form hetero or homodimers and serve as anti or pro-apoptotic regulators which are involved in a wide variety of cellular activities. BCL2L10 includes the conserved BH4, BH1 and BH2 domains. BCL2L10 interacts with other members of BCL2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. BCL2L10 overexpression suppresses cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and consequently activating caspase-3 activation.
BCL2L10 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (1-172 a.a.) and having a molecular mass of 21.8kDa.BCL2L10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 15q21 Cellular Component: mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; integral to membrane; cytosol Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HD36 |
| NCBI GenInfo Identifier: | 13898394 |
| NCBI Gene ID: | 10017 |
| NCBI Accession: | AAK48715.1 |
| UniProt Secondary Accession: | Q9HD36,Q3SX80, Q52LQ9, Q8TCS9, |
| UniProt Related Accession: | Q9HD36 |
| Molecular Weight: | 23 kDa |
| NCBI Full Name: | BCLB |
| NCBI Synonym Full Names: | BCL2-like 10 (apoptosis facilitator) |
| NCBI Official Symbol: | BCL2L10�� |
| NCBI Official Synonym Symbols: | Boo; Diva; BCL-B; bcl2-L-10�� |
| NCBI Protein Information: | bcl-2-like protein 10 |
| UniProt Protein Name: | Bcl-2-like protein 10 |
| UniProt Synonym Protein Names: | Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B |
| UniProt Gene Name: | BCL2L10�� |
| UniProt Entry Name: | B2L10_HUMAN |
