Human BAALC Recombinant Protein (RPPB2844)
- SKU:
- RPPB2844
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WXS3
Description
| Product Name: | Human BAALC Recombinant Protein |
| Product Code: | RPPB2844 |
| Size: | 10µg |
| Species: | Human |
| Target: | BAALC |
| Synonyms: | Brain and acute leukemia cytoplasmic protein, FLJ12015, BAALC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein solution contains 20mM Tris buffer pH-8, 1mM DTT, 20% glycerol and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDAPPSAA APDSGPEAGG LHSGMLEDGL PSNGVPRSTA PGGIPNPEKK TNCETQCPNP QSLSSGPLTQ KQNGLQTTEA KRDAKRMPAK EVTINVTDSI QQMDRSRRIT KNCVN |
BAALC gene is found in patients with acute myeloid leukemia and is conserved among mammals and is not found in lower organisms. Tissues which express BAALC develop from the neuroectoderm. BAALC is located both in the membrane and in the cytoplasma, it exists as multiple alternatively spliced isoform. Overexpression of BAALC concomitant forecast adverse clinical outcome and defines a significant risk factor in cytogenetically normal acute myeloid leukemia (AML).
BAALC Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-145 a.a.) and having a molecular mass of 17.7 kDa. The BAALC protein is fused to a 20 amino acid His Tag at N-terminus and purified by standard chromatogrpahy techniques.
| UniProt Protein Function: | BAALC: May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8q22.3 Cellular Component: cytoplasm |
| NCBI Summary: | This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WXS3 |
| NCBI GenInfo Identifier: | 74730996 |
| NCBI Gene ID: | 79870 |
| NCBI Accession: | Q8WXS3.3 |
| UniProt Secondary Accession: | Q8WXS3,Q8WTP6, Q8WXS0, Q8WXS1, Q8WXS2, Q9HA93, |
| UniProt Related Accession: | Q8WXS3 |
| Molecular Weight: | 5,663 Da |
| NCBI Full Name: | Brain and acute leukemia cytoplasmic protein |
| NCBI Synonym Full Names: | brain and acute leukemia, cytoplasmic |
| NCBI Official Symbol: | BAALC�� |
| NCBI Protein Information: | brain and acute leukemia cytoplasmic protein |
| UniProt Protein Name: | Brain and acute leukemia cytoplasmic protein |
| Protein Family: | Brain and acute leukemia cytoplasmic protein |
| UniProt Gene Name: | BAALC�� |
| UniProt Entry Name: | BAALC_HUMAN |
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