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Human B3GNT2 Recombinant Protein (RPPB1435)

SKU:
RPPB1435
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NY97
Research Area:
Enzymes
$371
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Description

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Product Name:Human B3GNT2 Recombinant Protein
Product Code:RPPB1435
Size:5µg
Species:Human
Target:B3GNT2
Synonyms:B3GNT2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT,BGnT-2, BGNT2, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase2, Beta-1,3-N-acetylglucosaminyltransferase 1, BGnT-1, Beta-1,3-Gn-T1,Beta3Gn-T1, Beta-1,3-galactosyltransferase 7, Beta-1,3-GalTase 7, Beta3Gal-T7,Beta3GalT7,b3Gal-T7, Beta-3-Gx-T7, beta-GlcNAcbeta-1,3-galactosyltransferase 7, betaGalbeta-1,3-N-acetylglucosaminyltransferase 2, BGnT-2, Beta-1,3-Gn-T2,Beta-1,3-N-acetylglucosaminyltransferase 2, Beta3Gn-T2,beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:B3GNT2 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPKSSSQEKNGKGEVIIPK EKFWKISTPP EAYWNREQEK LNRQYNPILS MLTNQTGEAG RLSNISHLNY CEPDLRVTSVVTGFNNLPDR FKDFLLYLRC RNYSLLIDQP DKCAKKPFLL LAIKSLTPHF ARRQAIRESW GQESNAGNQTVVRVFLLGQT PPEDNHPDLS DMLKFESEKH QDILMWNYRD TFFNLSLKEV LFLRWVSTSC PDTEFVFKGDDDVFVNTHHI LNYLNSLSKT KAKDLFIGDV IHNAGPHRDK KLKYYIPEVV YSGLYPPYAG GGGFLYSGHLALRLYHITDQ VHLYPIDDVY TGMCLQKLGL VPEKHKGFRT FDIEEKNKNN ICSYVDLMLV HSRKPQEMID IWSQLQSAHLKCHHHHHH

Beta-1,3-N-Acetylglucosaminyltransferase2 (B3GNT2) is a part of the beta-1,3-N-acetylglucosaminyltransferase familywhich takes part in the synthesis of poly-N-acetyllactosamine. B3GNT2 is a type II transmembrane proteinwhich prefers the substrate of lacto-N-neotetraose. B3GNT2 catalyzes theinitiation and elongation of poly-N-acetyllactosamine chains and comprises themain polylactosamine synthase.

B3GNT2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 375 amino acids (29-397a.a.) and havinga molecular mass of 43.5kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).B3GNT2 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:B3GNT2: Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Cell development/differentiation; Glycan Metabolism - keratan sulfate biosynthesis; Transferase; Motility/polarity/chemotaxis; Membrane protein, integral; EC 2.4.1.-

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Golgi membrane; integral to membrane

Molecular Function:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Biological Process: axon guidance; keratan sulfate biosynthetic process; O-glycan processing; poly-N-acetyllactosamine biosynthetic process; sensory perception of smell

NCBI Summary:This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Code:Q9NY97
NCBI GenInfo Identifier:9845238
NCBI Gene ID:10678
NCBI Accession:NP_006568.2
UniProt Secondary Accession:Q9NY97,Q54AC1, Q9NQQ9, Q9NQR0, Q9NUT9,
UniProt Related Accession:Q9NY97
Molecular Weight:
NCBI Full Name:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
NCBI Synonym Full Names:UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
NCBI Official Symbol:B3GNT2��
NCBI Official Synonym Symbols:B3GNT; BGNT2; B3GNT1; BGnT-2; beta-1; 3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT-2; BETA3GNT; beta3Gn-T1; beta3Gn-T2��
NCBI Protein Information:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
UniProt Protein Name:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
UniProt Synonym Protein Names:Beta-1,3-N-acetylglucosaminyltransferase 1; BGnT-1; Beta-1,3-Gn-T1; Beta3Gn-T1; Beta-1,3-galactosyltransferase 7; Beta-1,3-GalTase 7; Beta3Gal-T7; Beta3GalT7; b3Gal-T7; Beta-3-Gx-T7; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2; BGnT-2; Beta-1,3-Gn-T2; Beta-1,3-N-acetylglucosaminyltransferase 2; Beta3Gn-T2; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7
Protein Family:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
UniProt Gene Name:B3GNT2��
UniProt Entry Name:B3GN2_HUMAN

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