| Sequence: | Met 1- Ala 146 |
| Accession: | Q9ULK2-2 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | ATXN7 is found in the cytoplasm of all the populations of neurons analyzed in control brains, but nuclear labeling is observed in some neurons with a frequency and intensity weakly correlated with the topography of lesions in patients. Ataxin-7 is a component of the Tata binding protein (TBP)-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA), which is implicated in several steps of transcriptional regulation such as histone acetylation/deubiquitinylation and recruitment of the preinitiation complex to promoters. |
