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Human ATP1B2 Recombinant Protein (RPPB2820)

SKU:
RPPB2820
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P14415
€309
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Description

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Product Name:Human ATP1B2 Recombinant Protein
Product Code:RPPB2820
Size:20µg
Species:Human
Target:ATP1B2
Synonyms:ATPase Na+/K+ Transporting Beta 2 Polypeptide, Sodium-Potassium ATPase Subunit Beta 2 (Non-Catalytic), Sodium/Potassium-Dependent ATPase Beta-2 Subunit, Sodium/Potassium-Transporting ATPase Beta-2 Chain, Adhesion Molecule On Glia, Na K-ATPase Beta-2 Polypeptide, Sodium Pump Subunit Beta-2, AMOG.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The ATP1B2 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSDHTPKYQ DRLATPGLMI RPKTENLDVI VNVSDTESWD QHVQKLNKFL EPYNDSIQAQ KNDVCRPGRY YEQPDNGVLN YPKRACQFNR TQLGNCSGIG DSTHYGYSTG QPCVFIKMNR VINFYAGANQ SMNVTCAGKR DEDAENLGNF VMFPANGNID LMYFPYYGKK FHVNYTQPLV AVKFLNVTPN VEVNVECRIN AANIATDDER DKFAGRVAFK LRINKT

ATPaseTransporting Beta 2 (ATP1B2) is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The precise function of the beta-2 subunit is not known. The ATP1B2 protein is composed of 3 subunits: alpha (catalytic), beta and gamma.

ATP1B2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (68-246) and having a molecular mass of 27.8kDa.ATP1B2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ATP1B2: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complex

Molecular Function:ATPase activator activity; ATPase binding; protein binding; sodium:potassium-exchanging ATPase activity

Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport

NCBI Summary:The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Code:P14415
NCBI GenInfo Identifier:125987795
NCBI Gene ID:482
NCBI Accession:P14415.3
UniProt Secondary Accession:P14415,O60444, A0AV17, A8K278, D3DTQ2,
UniProt Related Accession:P14415
Molecular Weight:33,367 Da
NCBI Full Name:Sodium/potassium-transporting ATPase subunit beta-2
NCBI Synonym Full Names:ATPase Na+/K+ transporting subunit beta 2
NCBI Official Symbol:ATP1B2��
NCBI Official Synonym Symbols:AMOG��
NCBI Protein Information:sodium/potassium-transporting ATPase subunit beta-2
UniProt Protein Name:Sodium/potassium-transporting ATPase subunit beta-2
UniProt Synonym Protein Names:Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2
Protein Family:Sodium/potassium-transporting ATPase
UniProt Gene Name:ATP1B2��
UniProt Entry Name:AT1B2_HUMAN

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