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Human ASRGL1 Recombinant Protein (RPPB1425)

SKU:
RPPB1425
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q7L266
Research Area:
Enzymes
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Description

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Product Name:Human ASRGL1 Recombinant Protein
Product Code:RPPB1425
Size:10µg
Species:Human
Target:ASRGL1
Synonyms:ALP, ALP1, CRASH, ,Beta-aspartyl-peptidase, Isoaspartyl dipeptidase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ASRGL1 protein solution (0.5mg/ml) containing Phosphatebuffer saline, (pH 7.4) ,10% glycerol and1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNPIVVV HGGGAGPISK DRKERVHQGM VRAATVGYGI LREGGSAVDAVEGAVVALED DPEFNAGCGS VLNTNGEVEM DASIMDGKDL SAGAVSAVQC IANPIKLARL VMEKTPHCFLTDQGAAQFAA AMGVPEIPGE KLVTERNKKR LEKEKHEKGA QKTDCQKNLG TVGAVALDCK GNVAYATSTGGIVNKMVGRV GDSPCLGAGG YADNDIGAVS TTGHGESILK VNLARLTLFH IEQGKTVEEA ADLSLGYMKSRVKGLGGLIV VSKTGDWVAK WTSTSMPWAA AKDGKLHFGI DPDDTTITDL P

ASRGL1 is a 308 amino acid protein which is a member of the Ntn-hydrolase family. ASRGL1 is an autoantigenic protein which is present in the mid-piece of sperm after obstruction of the male reproductive tract. ASRGL1 is expressed highly in the testis, but is also expressed in the brain, kidney and gastrointestinal tissues. High levels of ASRGL1 are also detected in ovarian, uterine and mammary tumors in comparison with normal tissues of the same origin.

ASRGL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 331 amino acids (1-308 a.a) and having a molecular mass of 34.4kDa.ASRGL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ASRGL1: Acts in asparagine catabolism. May be involved in astroglial production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Belongs to the Ntn-hydrolase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Other Amino Acids Metabolism - cyanoamino acid; Energy Metabolism - nitrogen; Amino Acid Metabolism - alanine, aspartate and glutamate; Hydrolase; EC 3.5.1.1; EC 3.4.19.5

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: cytoplasm; nucleus

Molecular Function:asparaginase activity; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; beta-aspartyl-peptidase activity

Biological Process: asparagine catabolic process via L-aspartate; proteolysis

UniProt Code:Q7L266
NCBI GenInfo Identifier:127798426
NCBI Gene ID:80150
NCBI Accession:AAH21295.3
UniProt Secondary Accession:Q7L266,Q567Q4, Q6P1P0, Q8NI34, Q9H6F7, B2R7Q0,
UniProt Related Accession:Q7L266
Molecular Weight:18,981 Da
NCBI Full Name:Asparaginase like 1
NCBI Synonym Full Names:asparaginase like 1
NCBI Official Symbol:ASRGL1��
NCBI Official Synonym Symbols:ALP; ALP1; CRASH��
NCBI Protein Information:isoaspartyl peptidase/L-asparaginase; beta-aspartyl-peptidase; isoaspartyl dipeptidase; L-asparagine amidohydrolase; asparaginase-like 1 protein; asparaginase-like protein 1
UniProt Protein Name:Isoaspartyl peptidase/L-asparaginase
UniProt Synonym Protein Names:Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolaseCleaved into the following 2 chains:Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain
UniProt Gene Name:ASRGL1��
UniProt Entry Name:ASGL1_HUMAN

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