Human ASPRV1 Recombinant Protein (RPPB1424)
- SKU:
- RPPB1424
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q53RT3
- Research Area:
- Enzymes
Description
| Product Name: | Human ASPRV1 Recombinant Protein |
| Product Code: | RPPB1424 |
| Size: | 20µg |
| Species: | Human |
| Target: | ASPRV1 |
| Synonyms: | Retroviral-like aspartic protease 1, Skin-specific retroviral-like aspartic protease, SASPase, Skin aspartic protease, TPA-inducible aspartic proteinase-like protein, TAPS, ASPRV1, SASP, MUNO. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The ASPRV1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSMGKGYY LKGKIGKVPV RFLVDSGAQV SVVHPNLWEE VTDGDLDTLQ PFENVVKVAN GAEMKILGVW DTAVSLGKLK LKAQFLVANA SAEEAIIGTD VLQDHNAILD FEHRTCTLKG KKFRLLPVGG SLEDEFDLE |
Aspartic Peptidase, Retroviral-Like 1 (ASPRV1) is a protein which contains one peptidase A2 domain. ASPRV1 undergoes autocleavage which is essential for activation of the protein. ASPRV1 is expressed mostly in the granular layer of the epidermis and inner root sheath of hair follicles and localized to membrane region. In the psoriatic skin, ASPRV1 is expressed throughout the stratum corneum. In the ulcerated skin, ASPRV1 is expressed in the stratum granulosum of intact epidermis; however it is virtually nonexistent from ulcerated regions. In addition, ASPRV1 is expressed in differentiated areas of squamous cell carcinomas but not in the undifferentiated tumors.
ASPRV1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 159 amino acids (191-326) and having a molecular mass of 17.2kDa.ASPRV1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ASPRV1: Homodimer (Potential).Protein type: Protease; Membrane protein, integral; EC 3.4.23.-Chromosomal Location of Human Ortholog: 2p13.3Cellular Component: integral to membraneMolecular Function: aspartic-type endopeptidase activityBiological Process: skin development; protein processing; proteolysis |
| UniProt Protein Details: | |
| NCBI Summary: | Filaggrin is a structural protein that is crucial for in the development and maintenance of the skin barrier. This gene encodes a retroviral-like protease involved in profilaggrin-to-filaggrin processing. Expression is found primarily in the epidermis and inner root sheath of hair follicles. [provided by RefSeq, May 2017] |
| UniProt Code: | Q53RT3 |
| NCBI GenInfo Identifier: | 189409122 |
| NCBI Gene ID: | 151516 |
| NCBI Accession: | NP_690005 |
| UniProt Secondary Accession: | Q53RT3 |
| UniProt Related Accession: | Q53RT3 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | retroviral-like aspartic protease 1 |
| NCBI Synonym Full Names: | aspartic peptidase retroviral like 1 |
| NCBI Official Symbol: | ASPRV1�� |
| NCBI Official Synonym Symbols: | MUNO; SASP; Taps; SASPase�� |
| NCBI Protein Information: | retroviral-like aspartic protease 1 |
| UniProt Protein Name: | Retroviral-like aspartic protease 1 |
| UniProt Synonym Protein Names: | Skin-specific retroviral-like aspartic protease; SASPase; Skin aspartic protease; TPA-inducible aspartic proteinase-like protein; TAPS |
| Protein Family: | |
| UniProt Gene Name: | ASPRV1�� |
| UniProt Entry Name: | APRV1_HUMAN |
