Human ASGR2 Recombinant Protein (RPPB2807)
- SKU:
- RPPB2807
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P07307
Description
| Product Name: | Human ASGR2 Recombinant Protein |
| Product Code: | RPPB2807 |
| Size: | 20µg |
| Species: | Human |
| Target: | ASGR2 |
| Synonyms: | Asialoglycoprotein receptor 2, ASGP-R 2, ASGPR 2, C-type lectin domain family 4 member H2, Hepatic lectin H2, HL-2, ASGR2, CLEC4H2, HBXBP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ASGR2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSQSEGHRG AQLQAELRSL KEAFSNFSSS TLTEVQAIST HGGSVGDKIT SLGAKLEKQQ QDLKADHDAL LFHLKHFPVD LRFVACQMEL LHSNGSQRTC CPVNWVEHQG SCYWFSHSGK AWAEAEKYCQ LENAHLVVIN SWEEQKFIVQ HTNPFNTWIG LTDSDGSWKW VDGTDYRHNY KNWAVTQPDN WHGHELGGSE DCVEVQPDGR WNDDFCLQVY RWVCEKRRNA TGEVA |
Asialoglycoprotein Receptor 2 (ASGR2) is a hetero-oligomeric protein comprised of major and minor subunits, encoded by different genes. ASGR2 is a subunit of the asialoglycoprotein receptor; it is the less abundant minor subunit. The ASGR2 receptor is a transmembrane protein, which has a crucial role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues.
ASGR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 255 amino acids (80-311 a.a) and having a molecular mass of 28.9kDa.ASGR2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ASGP-R: cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane Molecular Function:asialoglycoprotein receptor activity; protein binding Biological Process: cell surface receptor linked signal transduction; protein amino acid N-linked glycosylation via asparagine |
| NCBI Summary: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P07307 |
| NCBI GenInfo Identifier: | 218511923 |
| NCBI Gene ID: | 433 |
| NCBI Accession: | P07307.2 |
| UniProt Secondary Accession: | P07307,O00448, Q03969, A6NLV8, A8MT12, D3DTM9, D3DTN0 |
| UniProt Related Accession: | P07307 |
| Molecular Weight: | 35kDa |
| NCBI Full Name: | Asialoglycoprotein receptor 2 |
| NCBI Synonym Full Names: | asialoglycoprotein receptor 2 |
| NCBI Official Symbol: | ASGR2�� |
| NCBI Official Synonym Symbols: | HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2�� |
| NCBI Protein Information: | asialoglycoprotein receptor 2 |
| UniProt Protein Name: | Asialoglycoprotein receptor 2 |
| UniProt Synonym Protein Names: | C-type lectin domain family 4 member H2; Hepatic lectin H2; HL-2 |
| Protein Family: | Asialoglycoprotein receptor |
| UniProt Gene Name: | ASGR2�� |
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