Human ARPC2 Recombinant Protein (RPPB2798)
- SKU:
- RPPB2798
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O15144
Description
| Product Name: | Human ARPC2 Recombinant Protein |
| Product Code: | RPPB2798 |
| Size: | 10µg |
| Species: | Human |
| Target: | ARPC2 |
| Synonyms: | ARC34, p34-Arc, PNAS-139, PRO2446, Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subuni, ARPC2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ARPC2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 50% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMILLEVN NRIIEETLAL KFENAAAGNK PEAVEVTFAD FDGVLYHISN PNGDKTKVMV SISLKFYKEL QAHGADELLK RVYGSFLVNP ESGYNVSLLY DLENLPASKD SIVHQAGMLK RNCFASVFEK YFQFQEEGKE GENRAVIHYR DDETMYVESK KDRVTVVFST VFKDDDDVVI GKVFMQEFKE GRRASHTAPQ VLFSHREPPL ELKDTDAAVG DNIGYITFVL FPRHTNASAR DNTINLIHTF RDYLHYHIKC SKAYIHTRMR AKTSDFLKVL NRARPDAEKK EMKTITGKTF SSR |
Actin-related protein 2/3 complex subunit 2 (ARPC2), is a part of the Rho family of small GTPases and one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. Nevertheless, the exact role of the protein (the p34 subunit) has yet to be determined.
ARPC2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (1-300a.a) and having a molecular mass of 36.7kDa. ARPC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q36.1 Cellular Component: Golgi apparatus; Arp2/3 protein complex; neuron projection; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility |
| NCBI Summary: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15144 |
| NCBI GenInfo Identifier: | 3121764 |
| NCBI Gene ID: | 10109 |
| NCBI Accession: | O15144.1 |
| UniProt Secondary Accession: | O15144,Q92801, Q9P1D4, |
| UniProt Related Accession: | O15144 |
| Molecular Weight: | 34,333 Da |
| NCBI Full Name: | Actin-related protein 2/3 complex subunit 2 |
| NCBI Synonym Full Names: | actin related protein 2/3 complex, subunit 2, 34kDa |
| NCBI Official Symbol: | ARPC2�� |
| NCBI Official Synonym Symbols: | ARC34; PRO2446; p34-Arc; PNAS-139�� |
| NCBI Protein Information: | actin-related protein 2/3 complex subunit 2; ARP2/3 protein complex subunit 34; arp2/3 complex 34 kDa subunit |
| UniProt Protein Name: | Actin-related protein 2/3 complex subunit 2 |
| UniProt Synonym Protein Names: | Arp2/3 complex 34 kDa subunit; p34-ARC |
| UniProt Gene Name: | ARPC2�� |
| UniProt Entry Name: | ARPC2_HUMAN |
