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Human ARMC10 Recombinant Protein (RPPB2796)

SKU:
RPPB2796
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8N2F6
$371
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Description

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Product Name:Human ARMC10 Recombinant Protein
Product Code:RPPB2796
Size:10µg
Species:Human
Target:ARMC10
Synonyms:Armadillo repeat-containing protein 10, Splicing variant involved in hepatocarcinogenesis protein, ARMC10, SVH.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ARMC10 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSTRGRRRG DRELGIRSSK SAEDLTDGSY DDVLNAEQLQ KLLYLLESTE DPVIIERALI TLGNNAAFSV NQAIIRELGG IPIVANKINH SNQSIKEKAL NALNNLSVNV ENQIKIKIYI SQVCEDVFSG PLNSAVQLAG LTLLTNMTVT NDHQHMLHSY ITDLFQVLLT GNGNTKVQVL KLLLNLSENP AMTEGLLRAQ VDSSFLSLYD SHVAKEILLR VLTLFQNIKN CLKIEGHLAV QPTFTEGSLF FLLHGEECAQ KIRALVDHHD AEVKEKVVTI IPKI

AMRC10 is a protein which contains an armadillo repeat and transmembrane domain. Upregulation of the AMRC10 gene has a role in hepatocellular carcinoma. AMRC10 decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, moreover it might play a role in cell growth and survival.

ARMC10 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 304 amino acids (28-308 a.a) and having a molecular mass of 33.6 kDa.ARMC10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ARMC10: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q22.1

NCBI Summary:This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
UniProt Code:Q8N2F6
NCBI GenInfo Identifier:74714720
NCBI Gene ID:83787
NCBI Accession:Q8N2F6.1
UniProt Secondary Accession:Q8N2F6,Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3 Q9BTM6, A8K703, B4DWJ8, F5GX65,
UniProt Related Accession:Q8N2F6
Molecular Weight:24,757 Da
NCBI Full Name:Armadillo repeat-containing protein 10
NCBI Synonym Full Names:armadillo repeat containing 10
NCBI Official Symbol:ARMC10��
NCBI Official Synonym Symbols:SVH; PNAS112; PNAS-112; PSEC0198��
NCBI Protein Information:armadillo repeat-containing protein 10
UniProt Protein Name:Armadillo repeat-containing protein 10
UniProt Synonym Protein Names:Splicing variant involved in hepatocarcinogenesis protein
Protein Family:Armadillo repeat-containing protein
UniProt Gene Name:ARMC10��
UniProt Entry Name:ARM10_HUMAN

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