Human ARL4D Recombinant Protein (RPPB2791)
- SKU:
- RPPB2791
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49703
Description
| Product Name: | Human ARL4D Recombinant Protein |
| Product Code: | RPPB2791 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARL4D |
| Synonyms: | ADP-ribosylation factor-like 4D, ADP-ribosylation factor-like protein 4L, ARF4L, ARL6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ARL4D solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.2M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL ERLYEMILKR KKAARGGKKR R |
ARL4D is a developmentally regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of Ras-related GTPases. Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). ARL4D takes part in membrane-associated intracellular trafficking. Mutations in this gene is linked to Bardet-Biedl syndrome (BBS).
ARL4D Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-201) and having a molecular mass of 24.3 kDa.ARL4D is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARL4D: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Belongs to the small GTPase superfamily. Arf family. |
| UniProt Protein Details: | Protein type:G protein; Nucleolus; G protein, monomeric; G protein, monomeric, ARF Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cytoplasm; nucleolus; plasma membrane Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: metabolic process; small GTPase mediated signal transduction; protein secretion |
| NCBI Summary: | ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49703 |
| NCBI GenInfo Identifier: | 41327767 |
| NCBI Gene ID: | 379 |
| NCBI Accession: | NP_001652.2 |
| UniProt Secondary Accession: | P49703,B2RC59, D3DX43, |
| UniProt Related Accession: | P49703 |
| Molecular Weight: | 22,156 Da |
| NCBI Full Name: | ADP-ribosylation factor-like protein 4D |
| NCBI Synonym Full Names: | ADP-ribosylation factor-like 4D |
| NCBI Official Symbol: | ARL4D�� |
| NCBI Official Synonym Symbols: | ARL6; ARF4L�� |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 4D; ADP-ribosylation factor-like 6; ADP-ribosylation factor-like protein 4L |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 4D |
| UniProt Synonym Protein Names: | ADP-ribosylation factor-like protein 4L |
| Protein Family: | ADP-ribosylation factor-like protein |
| UniProt Gene Name: | ARL4D�� |
| UniProt Entry Name: | ARL4D_HUMAN |
