Human ARL2 Recombinant Protein (RPPB2787)
- SKU:
- RPPB2787
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P36404
Description
| Product Name: | Human ARL2 Recombinant Protein |
| Product Code: | RPPB2787 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARL2 |
| Synonyms: | ADP-ribosylation factor-like protein 2, ARL2, ARFL2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ARL2 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.1mM PMSF, 1mM DTT and 40% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGLLTILKKM KQKERELRLL MLGLDNAGKT TILKKFNGED IDTISPTLGF NIKTLEHRGF KLNIWDVGGQ KSLRSYWRNY FESTDGLIWV VDSADRQRMQ DCQRELQSLL VEERLAGATL LIFANKQDLP GALSSNAIRE ALELDSIRSH HWCIQGCSAV TGENLLPGID WLLDDISSRI FTAD |
ARL2 is a member of the ADP-ribosylation factor (ARF) family. ARL2 functions as a component of a secretory pathway which is involved in the Ca2-dependent release of acetylcholine. ARL2 has a role in the folding of tubule proteins, thus playing a significant role in microtubule dynamics and cell cycle progression. Unlike other members of the ARF family, ARL2 doesn�t act as an activator of the catalytic subunit of cholera toxin.
ARL2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 204 amino acids (1-184 a.a.) and having a molecular mass of 23kDa. The ARL2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family. |
| UniProt Protein Details: | Protein type:G protein, monomeric, ARF; Mitochondrial; G protein, monomeric Chromosomal Location of Human Ortholog: 11q13 Cellular Component: centrosome; mitochondrial intermembrane space; nucleus; lateral plasma membrane Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; GTPase inhibitor activity Biological Process: tubulin folding; centrosome organization and biogenesis; metabolic process; small GTPase mediated signal transduction; positive regulation of microtubule polymerization; maintenance of protein localization in nucleus; cell cycle; regulation of microtubule polymerization |
| NCBI Summary: | This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P36404 |
| NCBI GenInfo Identifier: | 116241255 |
| NCBI Gene ID: | 402 |
| NCBI Accession: | P36404.4 |
| UniProt Related Accession: | P36404 |
| Molecular Weight: | |
| NCBI Full Name: | ADP-ribosylation factor-like protein 2 |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 2 |
| NCBI Official Symbol: | ARL2�� |
| NCBI Official Synonym Symbols: | ARFL2�� |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 2 |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 2 |
| Protein Family: | ADP-ribosylation factor-like protein |
| UniProt Gene Name: | ARL2�� |
| UniProt Entry Name: | ARL2_HUMAN |
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