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Human ARL11 Recombinant Protein (RPPB2784)

SKU:
RPPB2784
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q969Q4
€469

Description

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Product Name:Human ARL11 Recombinant Protein
Product Code:RPPB2784
Size:20µg
Species:Human
Target:ARL11
Synonyms:ADP-ribosylation factor-like protein 11, ADP-ribosylation factor-like tumor suppressor protein 1, ARL11, ARLTS1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ARL11 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 5mM DTT,30% glycerol, 100mM NaCl and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS

ARL11 (ADP-ribosylation factor-like protein 11) belongs to the ARF family of the Ras superfamily of small GTPases which are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins which enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they have a vital role in the activation of phospholipase D (PC-PLD). ARL11 is assumed to act as a tumor suppressor which may have a role in the regulation of apoptosis.

ARL11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-196 a.a.) and having a molecular mass of 23.6kDa.ARL11 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:May play a role in apoptosis. May act as a tumor suppressor.
NCBI Summary:This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
UniProt Code:Q969Q4
NCBI GenInfo Identifier:19923979
NCBI Gene ID:115761
NCBI Accession:NP_612459.1
UniProt Related Accession:Q969Q4
Molecular Weight:21,391 Da
NCBI Full Name:ADP-ribosylation factor-like protein 11
NCBI Synonym Full Names:ADP ribosylation factor like GTPase 11
NCBI Official Symbol:ARL11��
NCBI Official Synonym Symbols:ARLTS1��
NCBI Protein Information:ADP-ribosylation factor-like protein 11
UniProt Protein Name:ADP-ribosylation factor-like protein 11
UniProt Synonym Protein Names:ADP-ribosylation factor-like tumor suppressor protein 1
Protein Family:ADP-ribosylation factor-like protein
UniProt Gene Name:ARL11��

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