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Human APOBEC4 Recombinant Protein (RPPB2766)

SKU:
RPPB2766
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WW27
€309
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Description

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Product Name:Human APOBEC4 Recombinant Protein
Product Code:RPPB2766
Size:20µg
Species:Human
Target:APOBEC4
Synonyms:Apolipoprotein B MRNA Editing Enzyme, CatalyticPolypeptide-Like 4 (Putative), C1orf169, Apolipoprotein B MRNA-Editing EnzymeCatalytic Polypeptide-Like 4, Chromosome 1 Open Reading Frame 169, Putative C->U-EditingEnzyme APOBEC-4, EC 3.5.4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:APOBEC4 protein solution (1mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEPIYEE YLANHGTIVK PYYWLSFSLD CSNCPYHIRT GEEARVSLTEFCQIFGFPYG TTFPQTKHLT FYELKTSSGS LVQKGHASSC TGNYIHPESM LFEMNGYLDS AIYNNDSIRHIILYSNNSPC NEANHCCISK MYNFLITYPG ITLSIYFSQL YHTEMDFPAS AWNREALRSL ASLWPRVVLS PISGGIWHSV LHSFISGVSGSHVFQPILTG RALADRHNAY EINAITGVKP YFTDVLLQTK RNPNTKAQEA LESYPLNNAF PGQFFQMPSGQLQPNLPPDL RAPVVFVLVP LRDLPPMHMG QNPNKPRNIV RHLNMPQMSF QETKDLGRLP TGRSVEIVEI TEQFASSKEA DEKKKKKGKK

APOBEC4belongs to the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases,which convert cytidine to uridine. Further AID/APOBEC family members areimplicated in Mrna editing, somatic hypermutation and recombination ofimmunoglobulin genes, and innate immunity to retroviral infection. Among thediseases associated with APOBEC4 are systemic lupus erythematosus, and lupuserythematosus.

APOBEC4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 390 amino acids (1-367aa) and having a molecular mass of 44kDa.APOBEC4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:APOBEC4: Putative C to U editing enzyme whose physiological substrate is not yet known. Belongs to the cytidine and deoxycytidylate deaminase family.Protein type: Hydrolase; EC 3.5.4.-Chromosomal Location of Human Ortholog: 1q25.3
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WW27
NCBI GenInfo Identifier:74751569
NCBI Gene ID:403314
NCBI Accession:Q8WW27.1
UniProt Secondary Accession:Q8WW27,Q8N7F6
UniProt Related Accession:Q8WW27
Molecular Weight:41,581 Da
NCBI Full Name:Putative C->
NCBI Synonym Full Names:apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
NCBI Official Symbol:APOBEC4��
NCBI Official Synonym Symbols:C1orf169��
NCBI Protein Information:putative C->U-editing enzyme APOBEC-4
UniProt Protein Name:Putative C->U-editing enzyme APOBEC-4
UniProt Synonym Protein Names:Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Protein Family:Putative C->U-editing enzyme
UniProt Gene Name:APOBEC4��
UniProt Entry Name:ABEC4_HUMAN

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