Human ANP32A Recombinant Protein (RPPB2744)
- SKU:
- RPPB2744
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P39687
Description
| Product Name: | Human ANP32A Recombinant Protein |
| Product Code: | RPPB2744 |
| Size: | 10µg |
| Species: | Human |
| Target: | ANP32A |
| Synonyms: | I1PP2A, LANP, MAPM, PHAP1, Leucine-rich acidic nuclear protein, PP32, Mapmodulin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | ANP32A solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 100mM NaCl, 0.1mM PMSF and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEMGRRIHLE LRNRTPSDVK ELVLDNSRSN EGKLEGLTDE FEELEFLSTI NVGLTSIANL PKLNKLKKLE LSDNRVSGGL EVLAEKCPNL THLNLSGNKI KDLSTIEPLK KLENLKSLDL FNCEVTNLND YRENVFKLLP QLTYLDGYDR DDKEAPDSDA EGYVEGLDDE EEDEDEEEYD EDAQVVEDEE DEDEEEEGEE EDVSGEEEED EEGYNDGEVD DEEDEEELGE EERGQKRKRE PEDEGEDDD |
ANP32A often cooperate with MAP1B, TAF1A and Protein SET. ANP32A is involved in several cellular processes, such as proliferation, differentiation, caspase-dependent and caspase-independent apoptosis. Mapmodulin takes a part in E4F1-mediated transcriptional repression.
ANP32A Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 269 amino acids (1-249a.a.) and having a molecular mass of 30.7kDa. ANP32A is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ANP32A: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. Belongs to the ANP32 family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q23 Cellular Component: nucleoplasm; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus Molecular Function:protein binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleocytoplasmic transport; gene expression |
| UniProt Code: | P39687 |
| NCBI GenInfo Identifier: | 730318 |
| NCBI Gene ID: | 8125 |
| NCBI Accession: | P39687.1 |
| UniProt Secondary Accession: | P39687,Q53FK4, Q5J8L8, Q7M4N6, B2R6T4, |
| UniProt Related Accession: | P39687 |
| Molecular Weight: | 28,585 Da |
| NCBI Full Name: | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
| NCBI Synonym Full Names: | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
| NCBI Official Symbol: | ANP32A�� |
| NCBI Official Synonym Symbols: | LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1�� |
| NCBI Protein Information: | acidic leucine-rich nuclear phosphoprotein 32 family member A; mapmodulin; hepatopoietin Cn; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; putative HLA-DR-associated protein I; inhibitor-1 of protein phosphatase-2A; cerebellar leucine rich acidic nuclear protein; putative human HLA class II associated protein I; potent heat-stable protein phosphatase 2A inhibitor I1PP2A |
| UniProt Protein Name: | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
| UniProt Synonym Protein Names: | Acidic nuclear phosphoprotein pp32; pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Putative HLA-DR-associated protein I; PHAPI |
| Protein Family: | Acidic leucine-rich nuclear phosphoprotein 32 family |
| UniProt Gene Name: | ANP32A�� |
| UniProt Entry Name: | AN32A_HUMAN |
