Human ANGPTL2 Recombinant Protein (RPPB0035)
- SKU:
- RPPB0035
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UKU9
- Research Area:
- Cytokines
Description
| Product Name: | Human ANGPTL2 Recombinant Protein |
| Product Code: | RPPB0035 |
| Size: | 10µg |
| Species: | Human |
| Target: | ANGPTL2 |
| Synonyms: | Angiopoietin-related protein 2, Angiopoietin-like protein 2, ANGPTL2, ARP2, HARP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | ANGPTL2 was filtered (0.4 �m) and lyophilized from 0.5mg/ml in 0.03M Acetate buffer pH 4.0. |
| Solubility: | It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, an intensive dilution by relevant buffer to a concentration of 10?g/ml is recommended. In higher concentrations the solubility of the ANGPTL2 is limited. ANGPTL2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASQEDGFEGTEE GSPREFIYLN RYKRAGESQD KCTYTFIVPQ QRVTGAICVN SKEPEVLLEN RVHKQELELL NNELLKQKRQ IETLQQLVEV DGGIVSEVKL LRKESRNMNS RVTQLYMQLL HEIIRKRDNA LELSQLENRI LNQTADMLQL ASKYKDLEHK YQHLATLAHN QSEIIAQLEE HCQRVPSARP VPQPPPAAPP RVYQPPTYNR IINQISTNEI QSDQNLKVLP PPLPTMPTLT SLPSSTDKPS GPWRDCLQAL EDGHDTSSIY LVKPENTNRL MQVWCDQRHD PGGWTVIQRR LDGSVNFFRN WETYKQGFGN IDGEYWLGLE NIYWLTNQGN YKLLVTMEDW SGRKVFAEYA SFRLEPESEY YKLRLGRYHG NAGDSFTWHN GKQFTTLDRD HDVYTGNCAH YQKGGWWYNA CAHSNLNGVW YRGGHYRSRY QDGVYWAEFR GGSYSLKKVV MMIRPNPNTF H |
Angiopoietins belong to the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietins-1, 2 and 4 partake in the formation of blood vessels. ANGPTL2 displays angiogenic effects. Angiopoietin-like Protein 2 (ANGPTL2) is an anti-diabetic factor. ANGPTL2 induces sprouting in endothelial cells through an autocrine and paracrine action. ANGPTL2 increases insulin sensitivity in adipocytes. In addition, ANGPTL2 is a mediator of chronic adipose tissue inflammation. ANGPTL2 is widely expressed in the heart, small intestine, spleen and stomach. ANGPTL2 is also found in lower levels in the colon, ovary, adrenal gland, skeletal muscle and in prostate.
ANGPTL2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 481 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 56kDa (calculated).
| UniProt Protein Function: | ANGPTL2: Induces sprouting in endothelial cells through an autocrine and paracrine action. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q33.3 Cellular Component: extracellular space Molecular Function:receptor binding Biological Process: multicellular organismal development |
| NCBI Summary: | Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKU9 |
| NCBI GenInfo Identifier: | 6912236 |
| NCBI Gene ID: | 23452 |
| NCBI Accession: | NP_036230.1 |
| UniProt Secondary Accession: | Q9UKU9,Q5JT58, Q8NCH7, |
| UniProt Related Accession: | Q9UKU9 |
| Molecular Weight: | |
| NCBI Full Name: | angiopoietin-related protein 2 |
| NCBI Synonym Full Names: | angiopoietin like 2 |
| NCBI Official Symbol: | ANGPTL2�� |
| NCBI Official Synonym Symbols: | ARP2; HARP�� |
| NCBI Protein Information: | angiopoietin-related protein 2 |
| UniProt Protein Name: | Angiopoietin-related protein 2 |
| UniProt Synonym Protein Names: | Angiopoietin-like protein 2 |
| Protein Family: | Angiopoietin-related protein |
| UniProt Gene Name: | ANGPTL2�� |
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