Human AKR1A1 Recombinant Protein (RPPB1368)
- SKU:
- RPPB1368
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P14550
- Research Area:
- Enzymes
Description
| Product Name: | Human AKR1A1 Recombinant Protein |
| Product Code: | RPPB1368 |
| Size: | 20µg |
| Species: | Human |
| Target: | AKR1A1 |
| Synonyms: | Alcohol dehydrogenase, ALR, ARM, DD3, ALDR1, MGC1380, MGC12529, AKR1A1, Alcohol dehydrogenase [NADP+], Aldehyde reductase, Aldo-keto reductase family 1 member A1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | AKR1A1 solution containing 20mM Tris pH-8, 50mM NaCl and 10% glycerol. |
| Stability: | AKR1A1 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE PVVLALAEKY GRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY |
AKR1A1 is part of the aldo/keto reductase superfamily, it catalyzes the NADPH-dependent reduction from a range of aromatic and aliphatic aldehydes to their related alcohols. AKR1A1 corresponds (65% identity) to aldose reductase, an enzyme that takes part in the pathogenesis of some diabetic and galactosemic complications. AKR1A1 is involved in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs.
AKR1A1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 325 amino acids (1-325 a.a.) and having a molecular mass of 36.5 kDa. AKR1A1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family. |
| UniProt Protein Details: | Protein type:EC 1.1.1.2; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: cytosol; extracellular space Molecular Function:aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding Biological Process: aldehyde metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P14550 |
| NCBI GenInfo Identifier: | 113600 |
| NCBI Gene ID: | 10327 |
| NCBI Accession: | P14550.3 |
| UniProt Secondary Accession: | P14550,Q6IAZ4, A8KAL8, D3DQ04, |
| UniProt Related Accession: | P14550 |
| Molecular Weight: | 36,573 Da |
| NCBI Full Name: | Alcohol dehydrogenase |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member A1 |
| NCBI Official Symbol: | AKR1A1�� |
| NCBI Official Synonym Symbols: | ALR; ARM; DD3; ALDR1; HEL-S-6�� |
| NCBI Protein Information: | alcohol dehydrogenase [NADP(+)] |
| UniProt Protein Name: | Alcohol dehydrogenase [NADP(+)] |
| UniProt Synonym Protein Names: | Aldehyde reductase; Aldo-keto reductase family 1 member A1 |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | AKR1A1�� |
| UniProt Entry Name: | AK1A1_HUMAN |
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