Human AGA Recombinant Protein (RPPB1366)
- SKU:
- RPPB1366
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20933
- Research Area:
- Enzymes
Description
| Product Name: | Human AGA Recombinant Protein |
| Product Code: | RPPB1366 |
| Size: | 5µg |
| Species: | Human |
| Target: | AGA |
| Synonyms: | Aspartylglucosaminidase, Glycosylasparaginase,N4-(N-Acetyl-Beta-Glucosaminyl)-L-Asparagine Amidase,N(4)-(Beta-N-Acetylglucosaminyl)-L-Asparaginase , EC 3.5.1.26,Aspartylglucosylamine Deaspartylase, EC 3.5.1, ASRG, AGU, GA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | AGA protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPSSPLPLV VNTWPFKNATEAAWRALASG GSALDAVESG CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLEHTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG PYKPPGILKQDIPIHKETED DRGHDTIGMV VIHKTGHIAA GTSTNGIKFK IHGRVGDSPI PGAGAYADDT AGAAAATGNG DILMRFLPSYQAVEYMRRGE DPTIACQKVI SRIQKHFPEF FGAVICANVT GSYGAACNKL STFTQFSFMV YNSEKNQPTEEKVDCIHHHH HH |
Aspartylglucosaminidase, also known as AGA, takes part in the catabolism of Nlinked oligosaccharides of glycoproteins. AGA is a protein coding gene which cleaves asparagine from N-acetylglucosamines in the lysosomal breakdown of glycoproteins.
AGA produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 332 amino acids (24-346 a.a.) andhaving a molecular mass of 35.7kDa (Molecular size on SDS-PAGE will appear atapproximately 18-57kDa). AGA is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AGA: a catabolic enzyme, aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - other glycan degradation; EC 3.5.1.26; Hydrolase Chromosomal Location of Human Ortholog: 4q34.3 Cellular Component: endoplasmic reticulum; lysosome Molecular Function:peptidase activity; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; protein self-association Biological Process: protein deglycosylation; protein maturation; proteolysis Disease: Aspartylglucosaminuria |
| NCBI Summary: | Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P20933 |
| NCBI GenInfo Identifier: | 288558804 |
| NCBI Gene ID: | 175 |
| NCBI Accession: | P20933.2 |
| UniProt Secondary Accession: | P20933,Q4W5Q2, Q6FHN6, Q9UCK6, Q9UCK7, Q9UCK8, B2R7H2 D3DP47, |
| UniProt Related Accession: | P20933 |
| Molecular Weight: | 346 |
| NCBI Full Name: | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase |
| NCBI Synonym Full Names: | aspartylglucosaminidase |
| NCBI Official Symbol: | AGA�� |
| NCBI Official Synonym Symbols: | GA; AGU; ASRG�� |
| NCBI Protein Information: | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; glycosylasparaginase; aspartylglucosylamine deaspartylase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase |
| UniProt Protein Name: | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase |
| UniProt Synonym Protein Names: | Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidaseCleaved into the following 2 chains:Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain |
| Protein Family: | Agaricus bisporus lectin |
| UniProt Gene Name: | AGA�� |
| UniProt Entry Name: | ASPG_HUMAN |
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