Human ADFP Recombinant Protein (RPPB2703)
- SKU:
- RPPB2703
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99541
Description
| Product Name: | Human ADFP Recombinant Protein |
| Product Code: | RPPB2703 |
| Size: | 10µg |
| Species: | Human |
| Target: | ADFP |
| Synonyms: | Adipophilin, Adipose differentiation-related protein, ADRP, ADFP, MGC10598. |
| Source: | Escherichia Coli |
| Formulation: | Human ADFP was lyophilized from 0.5mg/ml solution containing 20mM Tris pH-7.5, and 20mM NaCl. |
| Solubility: | Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95% as determined by SDS PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS VAVDPQPSVV TRVVNLPLVS STYDLMSSAY LSTKDQYPYL KSVCEMAENG VKTITSVAMT SALPIIQKLE PQIAVANTYA CKGLDRIEER LPILNQPSTQ IVANAKGAVT GAKDAVTTTV TGAKDSVAST ITGVMDKTKG AVTGSVEKTK SVVSGSINTV LGSRMMQLVS SGVENALTKS ELLVEQYLPL TEEELEKEAK KVEGFDLVQK PSYYVRLGSL STKLHSRAYQ QALSRVKEAK QKSQQTISQL HSTVHLIEFA RKNVYSANQK IQDAQDKLYL SWVEWKRSIG YDDTDESHCA EHIESRTLAI ARNLTQQLQT TCHTLLSNIQ GVPQNIQDQA KHMGVMAGDI YSVFRNAASF KEVSDSLLTS SKGQLQKMKE SLDDVMDYLV NNTPLNWLVG PFYPQLTESQ NAQDQGAEMD KSSQETQRSEHKTH |
ADFP is related with the globule surface membrane material. ADFP is a major constituent of the globule surface. Rise in mRNA levels is one of the initial indications of adipocyte differentiation. Mycobacterium leprae regulates ADFP expression to facilitate the accumulation of lipids within infected macrophages for intracellular survival. ADFP is expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. ADFP expression has a role in clear cell renal carcinoma differentiation. ADFP is a component of the lipid droplets in THP-1 cells.
ADFP Human Recombinant produced in E.Coli is a signle, non-glycosylated, Polypeptide chain containing 444 amino acids and having a molecular mass of 49 kDa. The protein contains an extra 8 amino acid His tag at N-terminus. The ADFP amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q99541 amino acids 4�437.The ADFP is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | perilipin 2: May be involved in development and maintenance of adipose tissue. Belongs to the perilipin family. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum Chromosomal Location of Human Ortholog: 9p22.1 Cellular Component: endoplasmic reticulum; extracellular region; plasma membrane; lipid particle; nucleus; cytosol Biological Process: long-chain fatty acid transport; response to drug; sequestering of lipid; cellular lipid metabolic process; response to organic cyclic substance |
| NCBI Summary: | The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q99541 |
| NCBI GenInfo Identifier: | 34577059 |
| NCBI Gene ID: | 123 |
| NCBI Accession: | NP_001113.2 |
| UniProt Secondary Accession: | Q99541,Q9BSC3, |
| UniProt Related Accession: | Q99541 |
| Molecular Weight: | 48,075 Da |
| NCBI Full Name: | perilipin-2 |
| NCBI Synonym Full Names: | perilipin 2 |
| NCBI Official Symbol: | PLIN2�� |
| NCBI Official Synonym Symbols: | ADFP; ADRP�� |
| NCBI Protein Information: | perilipin-2; adipophilin; adipose differentiation-related protein |
| UniProt Protein Name: | Perilipin-2 |
| UniProt Synonym Protein Names: | Adipophilin; Adipose differentiation-related protein; ADRP |
| UniProt Gene Name: | PLIN2�� |
| UniProt Entry Name: | PLIN2_HUMAN |
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