Human ADA1B full length protein-synthetic nanodisc (HDFP175)
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- SKU:
- HDFP175
- Size:
- 10μg
- Target:
- ADA1B
- Tag:
- C-Flag Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
Description
| Product Name: | Nanodisc Human ADA1B Protein |
| SKU: | HDFP175 |
| Size: | 10μg |
| Target: | ADA1B |
| Tag: | C-Flag Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | ADRA1, ALPHA1BAR |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human ADA1B full length protein-synthetic nanodisc |
| Protein Pathways: | Calcium regulation in cardiac cells, GPCRDB Class A Rhodopsin-like, Monoamine GPCRs, Cell Cycle. |
| Molecular Weight: | The human full length ADA1B protein has a MW of 56.8kDa |
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
| Uniprot ID: | P35368 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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