Human ACTR3 Recombinant Protein (RPPB2699)
- SKU:
- RPPB2699
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61158
Description
| Product Name: | Human ACTR3 Recombinant Protein |
| Product Code: | RPPB2699 |
| Size: | 20µg |
| Species: | Human |
| Target: | ACTR3 |
| Synonyms: | ARP3 Actin-Related Protein 3 Homolog (Yeast), ARP3,Actin-Like Protein 3, ARP3 (Actin-Related Protein 3, Yeast) Homolog,Actin-Related Protein 3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ACTR3 protein solution (0.25 mg/ml) containing 20mMTris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAGRLPA CVVDCGTGYT KLGYAGNTEP QFIIPSCIAI KESAKVGDQAQRRVMKGVDD LDFFIGDEAI EKPTYATKWP IRHGIVEDWD LMERFMEQVI FKYLRAEPED HYFLLTEPPLNTPENREYTA EIMFESFNVP GLYIAVQAVL ALAASWTSRQVGERTLTGTV IDSGDGVTHV IPVAEGYVIG SCIKHIPIAG RDITYFIQQLLRDREVGIPP EQSLETAKAV KERYSYVCPD LVKEFNKYDT DGSKWIKQYT GINAISKKEF SIDVGYERFLGPEIFFHPEF ANPDFTQPIS EVVDEVIQNC PIDVRRPLYK NIVLSGGSTM FRDFGRRLQRDLKRTVDARL KLSEELSGGR LKPKPIDVQV ITHHMQRYAV WFGGSMLASTPEFYQVCHTK KDYEEIGPSI CRHNPVFGVM S |
ARP3 Actin-Related Protein 3, also known as ACTR3, belongs to the actinfamily. The specific function of ACTR3 has not been established yet. On theother hand, ACTR3 is identified as being a major constituent of the ARP2/3complex. In addition, this complex is located at the cell surface and vital tocell shape & motility through�lamellipodial actin assembly and protrusion. 3 transcript variantsencoding 2 different isoforms have been discovered for ACTR3.
ACTR3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 441 amino acids (1-418 a.a) andhaving a molecular mass of 49.8kDa.ACTR3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Arp3: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: Golgi membrane; Arp2/3 protein complex; focal adhesion; hemidesmosome; membrane; lamellipodium; excitatory synapse; podosome; actin filament; intercellular junction; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; ATP binding Biological Process: response to antibiotic; positive regulation of filopodium formation; axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; regulation of myosin II filament assembly or disassembly; establishment and/or maintenance of cell polarity; ephrin receptor signaling pathway; innate immune response; cytokinesis after meiosis; positive regulation of dendrite morphogenesis; cell motility; response to carbohydrate stimulus; spindle localization |
| NCBI Summary: | The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P61158 |
| NCBI GenInfo Identifier: | 47117647 |
| NCBI Gene ID: | 10096 |
| NCBI Accession: | P61158.3 |
| UniProt Secondary Accession: | P61158,P32391, Q53QM2, |
| UniProt Related Accession: | P61158 |
| Molecular Weight: | 47,371 Da |
| NCBI Full Name: | Actin-related protein 3 |
| NCBI Synonym Full Names: | ARP3 actin-related protein 3 homolog (yeast) |
| NCBI Official Symbol: | ACTR3�� |
| NCBI Official Synonym Symbols: | ARP3�� |
| NCBI Protein Information: | actin-related protein 3; actin-like protein 3 |
| UniProt Protein Name: | Actin-related protein 3 |
| UniProt Synonym Protein Names: | Actin-like protein 3 |
| UniProt Gene Name: | ACTR3�� |
| UniProt Entry Name: | ARP3_HUMAN |
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