Human ACTA2 Recombinant Protein (RPPB2698)
- SKU:
- RPPB2698
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62736
Description
| Product Name: | Human ACTA2 Recombinant Protein |
| Product Code: | RPPB2698 |
| Size: | 10µg |
| Species: | Human |
| Target: | ACTA2 |
| Synonyms: | Actin Alpha 2 Smooth Muscle Aorta, Cell Growth-Inhibiting Gene 46 Protein, Actin Aortic Smooth Muscle, Alpha-Cardiac Actin, Alpha-Actin-2, MYMY5, ACTSA, ACTVS, AAT6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ACTA2 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMEEEDS TALVCDNGSG LCKAGFAGDD APRAVFPSIV GRPRHQGVMV GMGQKDSYVG DEAQSKRGIL TLKYPIEHGI ITNWDDMEKI WHHSFYNELR VAPEEHPTLL TEAPLNPKAN REKMTQIMFE TFNVPAMYVA IQAVLSLYAS GRTTGIVLDS GDGVTHNVPI YEGYALPHAI MRLDLAGRDL TDYLMKILTE RGYSFVTTAE REIVRDIKEK LCYVALDFEN EMATAASSSS LEKSYELPDG QVITIGNERF RCPETLFQPS FIGMESAGIH ETTYNSIMKC DIDIRKDLYA NNVLSGGTTM YPGIADRMQK EITALAPSTM KIKIIAPPER KYSVWIGGSI LASLSTFQQM WISKQEYDEA GPSIVHRKCF |
ACTA2 is a member of the actin family of proteins, an extremely conserved family of proteins which takes part in cell motility, structure and integrity. Three types of actin isoforms are known: Alpha, beta and gamma. Alpha actins are a main factor of the contractile mechanism, and beta and gamma take part in the regulation of cell motility. ACTA2 is an alpha actin which is located in skeletal muscle. Mutations in ACTA2 cause aortic aneurysm familial thoracic type 6. Various alternatively spliced variants, encoding the same protein were identified.
ACTA2 Human Recombinant produced in E. coli is a single polypeptide chain containing 400 amino acids (3-377) and having a molecular mass of 44.4 kDa.ACTA2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family. |
| UniProt Protein Details: | Protein type:Contractile; Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q23.3 Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton Molecular Function:protein kinase binding; ATP binding Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6 |
| NCBI Summary: | The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008] |
| UniProt Code: | P62736 |
| NCBI GenInfo Identifier: | 51316972 |
| NCBI Gene ID: | 59 |
| NCBI Accession: | P62736.1 |
| UniProt Secondary Accession: | P62736,P03996, P04108, Q6FI19, B2R8A4, |
| UniProt Related Accession: | P62736 |
| Molecular Weight: | 42,009 Da |
| NCBI Full Name: | Actin, aortic smooth muscle |
| NCBI Synonym Full Names: | actin, alpha 2, smooth muscle, aorta |
| NCBI Official Symbol: | ACTA2�� |
| NCBI Official Synonym Symbols: | AAT6; ACTSA; MYMY5�� |
| NCBI Protein Information: | actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein |
| UniProt Protein Name: | Actin, aortic smooth muscle |
| UniProt Synonym Protein Names: | Alpha-actin-2; Cell growth-inhibiting gene 46 protein |
| Protein Family: | Actin |
| UniProt Gene Name: | ACTA2�� |
| UniProt Entry Name: | ACTA_HUMAN |
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